Abstract
Small ruminant lentiviruses infect sheep and goats worldwide, causing chronic progressive diseases and relevant economic losses. Disease eradication and prevention is mostly based on serological testing. The goal of this research was to investigate the presence of the small ruminant lentiviruses (SRLVs) in Jordan and to characterize the serological response in sheep and goat populations. A panel of sera were collected from flocks located in Northern Jordan and Jordan Valley. The samples were tested using three ELISA assays: a commercially available ELISA based on p25 recombinant protein and transmembrane peptide derived from British maedi–visna virus (MVV) EV1 strain, an ELISA based on P16-P25 recombinant protein derived from two Italian strains representative of MVV- and caprine arthritis encephalitis virus (CAEV)-like SRLVs, and an ELISA based on SU5 peptide from the same two Italian isolates. The results indicate that both MVV- and CAEV-like strains are present in Jordan and that the majority of the viruses circulating among sheep and goat populations belong to the MVV-like genotype.
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Alluwaimi, A., Abu Elzein, E.M.E. and Hassanein, M.M. (1990). Caprine arthritis encephalitis antibodies in indigenous sheep in Saudi Arabia, Revue Elevage Medicine Veterinary Pays Tropicaux, France, 43: 444–445.
Al-Qudah, K., Al-Majali, A.M., Ismail, Z.B., 2006. Epidemiological studies on caprine arthritis–encephalitis virus infection in Jordan, Small Ruminant Research, 66, 181–186.
Bertolotti, L., Mazzei, M., Puggioni, G., Carrozza, M.L., Dei Giudici, S., Muz, D., Juganaru, M., Patta, C., Tolari, F., Rosati, S. 2011. Characterization of new small ruminant lentivirus subtype B3 suggests animal trade within the Mediterranean Basin, Journal of General Virology, 92:1923–1929.
Blacklaws, B.A., 2012. Small ruminant lentiviruses: immunopathogenesis of visna-maedi and caprine arthritis and encephalitis virus, Comparative Immunology, Microbiology & Infectious Diseases, 35, 259–269.
Burgu, I., Akça, Y., Alkan, F., Ozkul, A., Karaoğlu, T., Cabalar, M. 1994. Antibody prevalence of caprine arthritis encephalitis virus (CAEV) in goats in Turkey, Deutsche tierärztliche Wochenschrift, 101:390–391.
Carrozza, M.L., Mazzei, M., Lacerenza, D., Del Chiaro, L., Giammarioli, M., Marini, C., Rutili, D., Rosati, S., Tolari, F., 2009. Seroconversion against SU5 derived synthetic peptides in sheep experimentally infected with different SRLV genotypes, Veterinary Microbiology 137, 369–374.
Giangaspero, M., Gruner, L., Nishikawa, H., Tabbaa, D., Vacirca, G., 1993a. Lungworms, maedi visna and mixed infections with respiratory viruses in Syrian Awassi sheep, Veterinary Research Communications, 17, 371–374.
Giangaspero, M., Tabbaa, D., Nishikawa, H., Vanopdenbosh, E., 1993b. Epidemiological survey of the Maedi Visna (MV) virus in Syrian Awassi sheep, Revue d'élevage et de médecine vétérinaire des pays tropicaux, 46, 431–434.
González, B., Reina, R., García, I., Andrés, S., Glaria, I., Alzueta, M., Mora, M.I., Jugo, B.M., Arrieta-Aguirre, I., de la Lastra, J.M., Rodríguez, D., Rodríguez, J.R., Esteban, M., Grilló, M.J., Blacklaws, B.A., Harkiss, G.D., Chebloune, Y., Luján, L., de Andrés, D., Amorena, B., 2005. Mucosal immunization of sheep with a Maedi-Visna virus (MVV) env DNA vaccine protects against early MVV productive infection, Vaccine, 29, 4342–4352.
Grego, E., Bertolotti, L., Carrozza, M.L., Profiti, M., Mazzei, M., Tolari, F., Rosati, S., 2005. Genetic and antigenic characterization of the matrix protein of two genetically distinct ovine lentiviruses, Veterinary Microbiology, 106, 179–185.
Grego, E., Bertolotti, L., Quasso, A., Profiti, M., Lacerenza, D., Muz, D., Rosati, S. 2007. Genetic characterization of small ruminant lentivirus in Italian mixed flocks: evidence for a novel genotype circulating in a local goat population, Journal of General Virology 88:3423–3427.
Hananeh, W., Barhoom, S., 2009. Outbreak of Maedi-Visna in Sheep and Goats in Palestine, World Applied Sciences Journal 7, 19–23.
Herrmann-Hoesing, L.M., 2010. Diagnostic Assays Used to Control Small Ruminant Lentiviruses, Journal of Veterinary Diagnostic Investigation, 22, 843–855.
Lacerenza, D., Giammarioli, M., Grego, E., Marini, C., Profiti, M., Rutili, D., Rosati, S., 2006. Antibody response in sheep experimentally infected with different small ruminant lentivirus genotypes, Veterinary Immunology and Immunopathology, 112, 264–271.
Leitner, G., Krifucks, O., Weisblit, L., Lavi, Y., Bernstein, S., Merin, U., 2010. The effect of caprine arthritis encephalitis virus infection on production in goats, Veterinary Journal, 183, 328–331.
Muz D, Oğuzoğlu TC, Rosati S, Reina R, Bertolotti L, Burgu I., 2013. First molecular characterization of visna/maedi viruses from naturally infected sheep in Turkey, Archives of virology. doi: 10.1007/s00705-012-1518-1
Nenci, C., Zahno, M.L., Vogt, H.R., Obexer-Ruff, G., Doherr, M.G., Zanoni, R., Peterhans, E., Bertoni, G., 2007. Vaccination with a T-cell-priming Gag peptide of caprine arthritis encephalitis virus enhances virus replication transiently in vivo, Journal of General Virology, 88, 1589–1593.
Niesalla, H., de Andrés, X., Barbezange, C., Fraisier, C., Reina, R., Arnarson, H., Biescas, E., Mazzei, M., McNeilly, T.N., Liu, C., Watkins, C., Perez, M., Carrozza, M.L., Bandecchi, P., Solano, C., Crespo, H., Glaria, I., Huard, C., Shaw, D.J., de Blas, I., de Andrés, D., Tolari, F., Rosati, S., Suzan-Monti, M., Andréssdottir, V., Torsteinsdottir, S., Petursson, G., Badiola, J., Lujan, L., Pepin, M., Amorena, B., Blacklaws, B., Harkiss, G.D., 2009. Systemic DNA immunization against ovine lentivirus using particle-mediated epidermal delivery and modified vaccinia Ankara encoding the gag and/or env genes, Vaccine, 27, 260–269.
Pétursson, G., Matthíasdóttir, S., Svansson, V., Andrésdóttir, V., Georgsson, G., Martin, A.H., Agnarsdóttir, G., Gísladóttir, E., Arnadóttir, S., Högnadóttir, S., Jónsson, S.R., Andrésson, O.S., Torsteinsdóttir, S., 2005. Mucosal vaccination with an attenuated maedi-visna virus clone, Vaccine, 23, 3223–3228.
Pisoni, G., Quasso, A., Moroni, P., 2005. Phylogenetic analysis of small ruminant lentivirus subtype B1 in mixed flocks: evidence for natural transmission from goats to sheep, Virology. 339, 147–152.
Preziuso, S., Or ME., Giammarioli M., Kayar, A., Feliziani, F., Gonul R., Farneti, S, Parkanyaramis, C., Valente, C., Cuteri, V., 2010. Maedi-visna virus in Turkish sheep: a preliminary serological survey using ELISA tests, Turkish Journal of Veterinary and Animal Sciences 34(3): 289–293.
Reina, R., Barbezange, C., Niesalla, H., de Andrés, X., Arnarson, H., Biescas, E., Mazzei, M., Fraisier, C., McNeilly, T.N., Liu, C., Perez, M., Carrozza, M.L., Bandecchi, P., Solano, C., Crespo, H., Glaria, I., Huard, C., Shaw, D.J., de Blas, I., De Andrés, D., Tolari, F., Rosati, S., Suzan-Monti, M., Andrésdottir, V., Torsteinsdottir, S., Petursson, G., Lujan, L., Pepin, M., Amorena, B., Blacklaws, B., Harkiss, G.D., 2008. Mucosal immunization against ovine lentivirus using PEI–DNA complexes and modified vaccinia Ankara encoding the gag and/or env genes, Vaccine, 26, 4494–4505.
Saman, E., Van Eynde, G., Lujan, L., Extramiana, B., Harkiss, G., Tolari, F., Gonzàlez, L., Amorena, B., Watt, N., Badiola, J., 1999. A new sensitive serological assay for detection of lentivirus infections in small ruminants, Clinical and diagnostic laboratory immunology, 6, 734–740.
Shah, C,. Huder, J.B., Böni, J., Schönmann, M., Mühlherr, J,. Lutz, H., Schüpbach, J., 2004. Direct evidence for natural transmission of small-ruminant lentiviruses of subtype A4 from goats to sheep and vice versa, Journal of Virology, 78, 7518–7522.
Torsteinsdóttir, S., Carlsdóttir, H.M., Svansson, V., Matthíasdóttir, S., Martin, A.H., Pétursson, G., 2007. Vaccination of sheep with Maedi-visna virus gag gene and protein, beneficial or harmful? Vaccine, 25, 6713–6720.
Zanoni, R.G., 1998. Phylogenetic analysis of small ruminant lentiviruses. Journal of General Virology, 79, 1951–1961.
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Tolari, F., Al-Ramadneh, W., Mazzei, M. et al. Small ruminant lentiviruses in Jordan: evaluation of sheep and goat serological response using recombinant and peptide antigens. Trop Anim Health Prod 45, 1335–1340 (2013). https://doi.org/10.1007/s11250-013-0366-7
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DOI: https://doi.org/10.1007/s11250-013-0366-7