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A copper(II) complex of the Schiff base from l-valine and 2-hydroxy-1-naphthalidene plus 1,10-phenanthroline: synthesis, crystal structure, and DNA interaction

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Abstract

A new Cu(II) complex, [Cu(naph-val)phen] (naph-val = Schiff base derived from 2-hydroxy-1-naphthaldehyde and l-valine, phen = 1,10-phenanthroline), has been synthesized and characterized by physicochemical methods. The crystal structure of the complex showed that there are four independent molecular structures in the crystallographic asymmetric unit, and each of them shows a distorted square-pyramidal CuN3O2 coordination geometry. In the crystal, the π − π stacking and intermolecular hydrogen bonds form a 2D network. The interactions between the Cu(II) complex and calf thymus DNA (CT-DNA) have been studied by spectroscopic methods, as well as viscosity and thermal denaturation measurements. The results indicate that the Cu(II) complex binds to CT-DNA in an intercalative mode. The cleavage reaction on pBR322 plasmid DNA has been investigated by agarose gel electrophoresis in the absence and presence of mercaptopropionic acid. The Cu(II) complex exhibits an efficient DNA cleavage activity.

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Acknowledgments

This project was supported by the Natural Science Foundation of Shandong Province of China (No. Y2004B02) and the Special-purpose Construction Project Foundation for “Taishan Scholar” of Shandong Province.

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Authors and Affiliations

  1. Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, 252059, People’s Republic of China

    Jinghong Li, Jianfang Dong, Hui Cui, Tao Xu & Lianzhi Li

  2. Department of Material Science, Shandong Polytechnic Technician College, Liaocheng, 252027, People’s Republic of China

    Jianfang Dong

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  1. Jinghong Li
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  2. Jianfang Dong
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  3. Hui Cui
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Correspondence to Lianzhi Li.

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Li, J., Dong, J., Cui, H. et al. A copper(II) complex of the Schiff base from l-valine and 2-hydroxy-1-naphthalidene plus 1,10-phenanthroline: synthesis, crystal structure, and DNA interaction. Transition Met Chem 37, 175–182 (2012). https://doi.org/10.1007/s11243-011-9572-1

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