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Synthesis, DNA-binding and photocleavage studies of cobalt(III) complexes [Co(bpy)2(dpta)]3+ and [Co(bpy)2(amtp)]3+

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Abstract

Two novel cobalt(III) mixed-polypyridyl complexes [Co(bpy)2(dpta)]3+ and [Co(bpy)2(amtp)]3+ (bpy = 2,2′-bipyridine, dpta = dipyrido-[3,2-a;2′,3′-c]-thien-[3,4-c]azine, amtp = 3-amino-1,2,4-triazino[5,6-f]-1,10-phenanthroline) have been synthesized and characterized. The interaction of CoIII complexes with calf thymus DNA was investigated by spectroscopic and viscosity measurements. Results suggest that the two complexes bind to DNA via an intercalative mode. Moreover, CoIII complexes have been found to promote the photocleavage of plasmid DNA pBR322 under irradiation at 365 nm. The mechanism studies reveal that hydroxyl radical (OH•) is likely to be the reactive species responsible for the cleavage of plasmid DNA by [Co(bpy)2(dpta)]3+ and superoxide anion radical (O •−2 ) acts as the key role in the cleavage reaction of plasmid DNA by [Co(bpy)2(amtp)]3+.

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Authors and Affiliations

  1. Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, 510275, P.R. China

    Bin Peng, Hui Chao, Bin Sun, Feng Gao & Liang-Nian Ji

  2. The Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510275, P.R. China

    Jian Zhang

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  1. Bin Peng
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  2. Hui Chao
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  3. Bin Sun
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  4. Feng Gao
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  5. Liang-Nian Ji
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  6. Jian Zhang
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Correspondence to Hui Chao.

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Peng, B., Chao, H., Sun, B. et al. Synthesis, DNA-binding and photocleavage studies of cobalt(III) complexes [Co(bpy)2(dpta)]3+ and [Co(bpy)2(amtp)]3+ . Transition Met Chem 32, 271–277 (2007). https://doi.org/10.1007/s11243-006-0161-7

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  • DOI: https://doi.org/10.1007/s11243-006-0161-7

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