Abstract
Current available evidence suggests that air pollution, especially particulate matter <10 μm in aerodynamic diameter (PM10), has acute and chronic effects on health. We aimed to evaluate the epidemiological association between 24-h PM10 levels and acute coronary syndrome (ACS). We analyzed the number of daily admissions at the emergency unit (ED) of patients with suspected ACS, and the number of daily diagnosis of ACS in the same local ED according to the 24-h PM10, over a nearly 3-month period. 209 out of the 1,688 patients admitted to the ED with a clinical suspicion of ACS had a definitive diagnosis of ACS. Whereas the mean number of ED admissions for suspected ACS did not differ significantly according to the 24-h levels of PM10 (18 ± 1 vs. 17 ± 1; P = 0.13), the mean number of diagnoses of ACS was 26% higher when the 24-h levels of PM10 were >50 μg/m3 (2.4 ± 0.2 vs. 1.9 ± 0.2; P = 0.03). A statistically significant association was also observed between 24-h PM10 levels and daily number of ACS diagnoses (r = 0.26; P < 0.001), but not between 24-h PM10 levels and daily ED accesses for suspected ACS (r = 0.12; P = 0.24). Taken together, these results support the existence of an epidemiologic association between air pollution and acute cardiovascular events.
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References
Kampa M, Castanas E (2008) Human health effects of air pollution. Environ Pollut 151:362–367
Lippi G, Favaloro EJ, Franchini M, Guidi GC (2008) Air pollution and coagulation testing: a new source of biological variability? Thromb Res 123:50–54
Schwartz J (1994) Air pollution and daily mortality: a review and meta-analysis. Environ Res 64:36–52
Dockery DW, Pope CA III (1994) Acute respiratory effects of particulate air pollution. Annu Rev Public Health 15:107–132
Katsouyanni K, Touloumi G, Spix C et al (1997) Short-term effects of ambient sulphur dioxide and particulate matter on mortality in 12 European cities: results from time series data from the APHEA project. Air pollution and health: a European approach. BMJ 314:1658–1663
Martin MA, Roberts S (2008) A regression approach for estimating multiday adverse health effects of PM10 when daily PM10 data are unavailable. Am J Epidemiol 167:1511–1517
Martuzzi M, Krzyzanowski M, Bertollini R (2003) Health impact assessment of air pollution: providing further evidence for public health action. Eur Respir J Suppl 40:86s–91s
Peters A, Dockery DW, Muller JE, Mittleman MA (2001) Increased particulate air pollution and the triggering of myocardial infarction. Circulation 103:281–285
Braga AL, Zanobetti A, Schwartz J (2001) The lag structure between particulate air pollution and respiratory and cardiovascular deaths in 10 US cities. J Occup Environ Med 43:927–933
Mann JK, Tager IB, Lurmann F, Segal M et al (2002) Air pollution and hospital admissions for ischemic heart disease in persons with congestive heart failure or arrhythmia. Environ Health Perspect 110:1247–1252
Zanobetti A, Schwartz J (2005) The effect of particulate air pollution on emergency admissions for myocardial infarction: a multicity case-crossover analysis. Environ Health Perspect 113:978–982
Lanki T, Pekkanen J, Aalto P et al (2006) Associations of traffic related air pollutants with hospitalisation for first acute myocardial infarction: the HEAPSS study. Occup Environ Med 63:844–851
von Klot S, Peters A, Aalto P, Health Effects of Particles on Susceptible Subpopulations (HEAPSS) Study Group et al (2005) Ambient air pollution is associated with increased risk of hospital cardiac readmissions of myocardial infarction survivors in five European cities. Circulation 112:3073–3079
Daniels MJ, Dominici F, Zeger SL, Samet JM (2004) The national morbidity, mortality, and air pollution study. Part III: PM10 concentration-response curves and thresholds for the 20 largest US cities. Res Rep Health Eff Inst 94(Pt 3):1–21
Pereira Filho MA, Pereira LA, Arbex FF et al (2008) Effect of air pollution on diabetes and cardiovascular diseases in São Paulo, Brazil. Braz J Med Biol Res 41:526–532
Berglind N, Bellander T, Forastiere F, HEAPSS Study Group et al (2009) Ambient air pollution and daily mortality among survivors of myocardial infarction. Epidemiology 20:110–118
Franchini M, Mannucci PM (2007) Short-term effects of air pollution on cardiovascular diseases: outcomes and mechanisms. J Thromb Haemost 5:2169–2174
Levy D, Sheppard L, Checkoway H et al (2001) A case-crossover analysis of particulate matter air pollution and out-of-hospital primary cardiac arrest. Epidemiology 12:193–199
Sullivan J, Ishikawa N, Sheppard L, Siscovick D, Checkoway H, Kaufman J (2003) Exposure to ambient fine particulate matter and primary cardiac arrest among persons with and without clinically recognized heart disease. Am J Epidemiol 157:501–509
Fano V, Cernigliaro A, Scondotto S et al (2005) Health effects of environmental contamination due to volcanic ash of Mount Etna in autumn 2002. Epidemiol Prev 29:180–187
Rosenlund M, Berglind N, Pershagen G, Hallqvist J, Jonson T, Bellander T (2006) Long-term exposure to urban air pollution and myocardial infarction. Epidemiology 17:383–390
Pope CA III, Muhlestein JB, May HT, Renlund DG, Anderson JL, Horne BD (2006) Ischemic heart disease events triggered by short-term exposure to fine particulate air pollution. Circulation 114:2443–2448
Colucci ME, Veronesi L, Roveda AM, Marangio E, Sansebastiano G (2006) Particulate matter (PM10) air pollution, daily mortality, and hospital admissions: recent findings. Ig Sanita Pubbl 62:289–304
Dolci A, Dominici R, Luraschi P, Panteghini M (2006) 10% CV concentration for the fourth generation Roche cardiac troponin T assay derived from Internal Quality Control data. Clin Chem Lab Med 44:1495–1496
Agenzia Regionale per la Prevenzione e Protezione Ambientale del Veneto (2009) http://www.arpa.veneto.it/bollettini/htm/rete_pm10.asp. Accessed 13 April 2009
The Council Of The European Union (2009) Council directive 1999/30/EC of 22 April 1999 relating to limit values for sulphur dioxide, nitrogen dioxide and oxides of nitrogen, particulate matter and lead in ambient air. http://europa.eu/scadplus/leg/en/lvb/l28098.htm. Accessed 13 April 2009
Apple FS, Wu AH (2001) Myocardial infarction redefined: role of cardiac troponin testing. Clin Chem 47:377–379
Simpson R, Williams G, Petroeschevsky A et al (2005) The short-term effects of air pollution on daily mortality in four Australian cities. Aust N Z J Public Health 29:205–212
Forastiere F, Stafoggia M, Picciotto S et al (2005) A case-crossover analysis of out-of-hospital coronary deaths and air pollution in Rome, Italy. Am J Respir Crit Care Med 172:1549–1555
Schwartz J (2001) Air pollution and blood markers of cardiovascular risk. Environ Health Perspect 109(Suppl 3):405–409
Rückerl R, Ibald-Mulli A, Koenig W et al (2006) Air pollution and markers of inflammation and coagulation in patients with coronary heart disease. Am J Respir Crit Care Med 173:432–441
Park SK, O’Neill MS, Vokonas PS et al (2008) Traffic-related particles are associated with elevated homocysteine: the VA normative aging study. Am J Respir Crit Care Med 178:283–289
Mar TF, Koenig JQ, Jansen K et al (2005) Fine particulate air pollution and cardiorespiratory effects in the elderly. Epidemiology 16:681–687
Rückerl R, Phipps RP, Schneider A et al (2007) Ultrafine particles and platelet activation in patients with coronary heart disease––results from a prospective panel study. Part Fibre Toxicol 4:1
Mills NL, Donaldson K, Hadoke PW et al (2009) Adverse cardiovascular effects of air pollution. Nat Clin Pract Cardiovasc Med 6:36–44
Schulz H (2006) Fine particulate matter––a health hazard for lungs and other organs? Pneumologie 60:611–615
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Lippi, G., Franchini, M., Montagnana, M. et al. Relationship between 24-h air pollution, emergency department admission and diagnosis of acute coronary syndrome. J Thromb Thrombolysis 29, 381–386 (2010). https://doi.org/10.1007/s11239-009-0369-4
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DOI: https://doi.org/10.1007/s11239-009-0369-4