Abstract
Essential thrombocytosis is a myeloproliferative disorder of unknown etiology manifested clinically by the overproduction of platelets in the absence of a definable cause. Platelet dysfunction in essential thrombocytosis results in both hemorrhage and thrombosis. It is one of the rare causes of ischemic cardiovascular events. Fewer than 20 cases of essential thrombocytosis with involvement of coronary arteries leading to acute coronary syndromes or myocardial infarction have been reported. We report a case of multiple coronary thrombosis involving the left anterior descending artery and circumflex artery and stent implantation to the subtotally stenotic right renal artery in a women with unstable angina pectoris, essential thrombocytosis and previous history of renal artery trombosis.
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References
Spivak JL (1998) Polycythemia vera and other myeloproliferative diseases. In: Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL and Longo DL as (eds). Harrison’s Principles of Internal Medicine. 14th edn. The McGraw-Hill Companies, Inc., New York, Vol. 1. pp. 683–684
Epstein E, Godel A (1934) Hamorrhagische thrombocythamie bei vascularer schrumfmilz. Virchow Arch 292:233
McIntyre KJ, Hoagland HC, Silverstein MN, Petitt RM (1991) Essential thrombocythemia in young adults. Mayo Clin Proc 66:149–154
Bolin RB, Okumura T, Jamieson GA (1977) Changes in distribution of platelet membrane glycoproteins in patients with myeloproliferative disorders. Am J Hematol 3:63–71
Carvalho ACA, Rau AK (1982) Acquired qualitative platelet defects. In: Colman RW, Hirsh J, Marder JV et al. (eds). Hemostasis and Thrombosis, 2nd edn. Lippincott JB, Philadelphia, p. 750
Kaywin P, McDonough M, Insel PA, Shattil SJ (1978) Platelet function in essential thrombocythemia: Decreased epinephrine responsiveness associated with a deficiency of platelet alpha-adrenergic receptors. N Engl J Med 299:505–509
Moore A, Nachman RL, Platelet Fc (1981) Receptor: Increased expression in myeloproliferative disease. J Clin Invest 67:1064–1071
Cooper B, Ahern D (1979) Characterization of the platelet prostaglandin D2 receptor. Loss of prostaglandin D2 receptors in platelets of patients with myeloproliferative disorders. J Clin Invest 64:586–590
Okuma M, Uchino H (1979) Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders. Blood 54:1258–1271
Rocca B, Ciabattoni G, Tartaglione R, et al (1995) Increased thromboxane biosynthesis in essential thrombocythemia. Thromb Haemost 74:1225–1230
Mitus AJ, Schafer AI (1990) Thrombocytosis and thrombocythemia. Hematol Oncol Clin North Am 4:157–178
Saffitz JE, Phillips ER, Temesy-Armos PN, Roberts WC (1983) Thrombocytosis and fatal coronary heart disease. Am J Cardiol 52:651–652
Pick RA, Glover MU, Nanfro JJ, Dubbs WF, Gibbons JA, Vieweg WV (1983) Acute myocardial infarction with essential thrombocythemia in a young man. Am Heart J 106:406–407
Koh KK, Cho SK, Kim SS, Oh BH, Lee YW (1993) Coronary vasospasm, multiple coronary thrombosis, unstable angina and essential thrombocytosis. Int J Cardiol 41:168–170
Host NB, Saunamaki KI (1992) Coronary heart disease in young age associated with essential thrombocythemia. Am Heart J 124:219–221
Turgut T, Harjai KJ, Edupuganti R, et al (1998) Acute coronary occlusion and in-stent thrombosis in a patient with essential thrombocythemia. Cathet Cardiovasc Diagn 45:428–433
Hamada Y, Matsuda Y, Fujii B, et al (1989) Multiple coronary thrombosis in a patient with thrombocytosis. Clin Cardiol 12:723–724
Michaels AD, Whisenant B, MacGregor JS (1998) Multivessel coronary thrombosis treated with abciximab (ReoPro) in a patient with essential thrombocythemia. Clin Cardiol 21:134–138
Momiyama T, Hiranaka T, Nomura F, Tominaga H, Nishioka T (1993) Coronary artery bypass grafting for left main trunk coronary artery lesion associated with essential thrombocythemia. Clin Cardiol 16:691–693
Douste-Blazy P, Taudou MJ, Delay M, et al (1984) Essential thrombocythemia and recurrent myocardial infarction. Lancet 2(8409):992
Joseph T, Hiltgen M, Gaulier A, Saudemont JP (1996) Myocardial infarction caused by thrombosis of the left coronary artery in a patient with thrombocythemia. Ann Cardiol Angeiol (Paris) 45:581–584
Terada H, Satoh H, Uehara A (2000) Multivessel coronary thrombosis, acute myocardial infarction, and no reflow in a patient with essential thrombocythemia. Heart 83:E10
Sganzerla P, Passaretti B, Ceriani R, Bortone F (2000) Cardiogenic shock due to acute left main coronary artery occlusion: successful treatment with primary angioplasty. Ital Heart J 1:702–704
Tariq M, Carroll R, Zabih I, Stenberg RG, Hussain KM (2002) Emergency coronary stenting for complete thrombotic occlusion of an unprotected left main coronary artery in acute myocardial infarction complicated by cardiogenic shock in an octogenarian patient—a case report. Angiology 53:95–98
Yoshida H, Hoshino T, Ishida T, Shiomura T, Kaburagi T (1991) Essential thrombocythemia associated with angina pectoris with unusual coronary artery findings. Chest 100:1162–1163
Yilmaz E, Bilge AK, Umman B, Mercanoglu F, Oncül A, Nisanci Y (2003) Acute anterior myocardial infarction in a young man with essential throbocythemia: A case report. Int J Angiol 12:138–142
Esteves FA, Costa FA, Lima AA, Kajita LJ, Martinez FEE (1999) Essential hrombocythemia and acute myocardial infarction treated with rescue coronary angioplasty. Arq Bras Cardiol 73:97–102
Kaya H, Gundogdu M, Tekin SB, Akarsu E, Bozkurt E (2000) Essential thrombocythemia and recurrent myocardial infarction. Clin Lab Haematol 22:161–162
Rossi C, Randi ML, Zerbinati P, Rinaldi V, Girolami A (1998) Acute coronary disease in essential thrombocythemia and polycythemia vera. J Intern Med 244:49–53
Arnar DO, Petursson MK, Jonmundsson E, Bjornsdottir J (1993) Renovascular hypertension and coronary heart disease complicating essential thrombocythemia. Eur Heart J 14:576–578
Bruch JS, Stein RS, Oates JA (1988) Hypertension complicating essential thrombocythemia. Am J Med Sci 295:466–468
Lagrue G, Antelin C, Kabaker M (1986) Essential thrombocythemia and hypertension as a result of stenosis of the renal artery. Arch Mal Coeur Vaiss 79:792–795
Bello NI, Conde ZJM, Barrientos GA, et al (1982) Essential thrombocytosis with acute renal failure due to bilateral thrombosis of the renal arteries and veins. Nephron 32:73–74
Kirubakaran MG, Shastry JC, Date A, Carman RH, Savarirayan SS, Johny KV (1975) Renal artery stenosis secondary to essential thrombocythemia. J Assoc Physicians India 23:213–216
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Ozben, B., Ekmekci, A., Bugra, Z. et al. Multiple coronary thrombosis and stent implantation to the subtotally occluded right renal artery in a patient with essential thrombocytosis: A case report with review. J Thromb Thrombolysis 22, 79–84 (2006). https://doi.org/10.1007/s11239-006-7790-8
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DOI: https://doi.org/10.1007/s11239-006-7790-8