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Contributions of specific and nonspecific interactions in the complexation of esters of 7-bromo-3-hydroxy-5-(o-chloro)phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-ones with central benzodiazepine receptors

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Theoretical and Experimental Chemistry Aims and scope

Radioligand analysis at 0-35 °C was used to find that 3-(alkylcarbonyloxy)-7-bromo-5-(o-chloro)phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-ones react differently with central benzodiazepine receptors. The complexation of the 3-acetyloxy derivative proceeds endothermally with ΔS 0 as the driving force. The reaction of the other esters is accompanied by favorable change of both entropy and enthalpy.

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This work was carried out with the financial support of the National Academy of Sciences of Ukraine within the framework of a cooperation agreement between the National Academy of Sciences of Ukraine and the National Center for Scientific Investigation of France (CNRS) (PICS 2010-2012).

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Authors and Affiliations

  1. O. V. Bogatskii Physico-Chemical Institute, Lustdorfs’ka Doroga, 86, Odesa, 65080, Ukraine

    S. A. Andronati, S. P. Smulsky, V. I. Pavlovsky, I. A. Boyko, T. A. Yurpalova & P. G. Polishchuk

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  1. S. A. Andronati
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  2. S. P. Smulsky
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  3. V. I. Pavlovsky
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  4. I. A. Boyko
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  5. T. A. Yurpalova
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  6. P. G. Polishchuk
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Corresponding author

Correspondence to S. A. Andronati.

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Translated from Teoreticheskaya i Éksperimental’naya Khimiya, Vol. 48, No. 5, pp. 297-302, September-October, 2012

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Andronati, S.A., Smulsky, S.P., Pavlovsky, V.I. et al. Contributions of specific and nonspecific interactions in the complexation of esters of 7-bromo-3-hydroxy-5-(o-chloro)phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-ones with central benzodiazepine receptors. Theor Exp Chem 48, 320–326 (2012). https://doi.org/10.1007/s11237-012-9276-4

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  • DOI: https://doi.org/10.1007/s11237-012-9276-4

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