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Electrochemical transformations and anti/prooxidant activity of sterically hindered o-benzoquinones

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Abstract

The electrochemical properties of a series of sterically hindered o-benzoquinones in aprotic solvents were examined. The reaction of O2 and KO2 with o-benzoquinones and electrogenerated o-semiquinone radical anions was studied. The formation of o-semiquinone radical anions in the reactions of KO2 with the studied o-quinones was detected using UV-visible and ESR spectroscopy. The influence of the test compounds on lipid peroxidation was considered at the molecular and tissue levels in vitro. In the most cases, o-quinones exhibit antioxidant activity, which varies depending on the type of lipid substrate.

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Authors and Affiliations

  1. Astrakhan State Technical University, 16 ul. Tatishcheva, 414056, Astrakhan, Russian Federation

    I. V. Smolyaninov, V. V. Kuzmin, S. A. Smolyaninova & N. T. Berberova

  2. Southern Scientific Center, Russian Academy of Sciences, 41 ul. Chekhova, 344006, Rostov-on-Don, Russian Federation

    I. V. Smolyaninov

  3. G. A. Razuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences, 49 ul. Tropinina, 603137, Nizhny Novgorod, Russian Federation

    M. V. Arsenyev & A. I. Poddel´sky

  4. N. I. Lobachevsky National Research Nizhny Novgorod State University, 23 prosp. Gagarina, 603950, Nizhny Novgorod, Russian Federation

    M. V. Arsenyev

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  1. I. V. Smolyaninov
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  2. V. V. Kuzmin
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1217—1229, July, 2017.

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Smolyaninov, I.V., Kuzmin, V.V., Arsenyev, M.V. et al. Electrochemical transformations and anti/prooxidant activity of sterically hindered o-benzoquinones. Russ Chem Bull 66, 1217–1229 (2017). https://doi.org/10.1007/s11172-017-1876-7

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