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Modification of gamma-carbolines with N-substituted propionamides as a new approach to mitoprotective agents

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Abstract

An approach to the modification of biologically active gamma-carbolines with the N-substituted propionamide fragments by the reaction of N-substituted acrylamides with gamma-carbolines catalyzed by cesium fluoride has been suggested. The compounds synthesized were studied for the influence on the functional characteristics of brain mitochondria, in particular, on the membrane potential, calcium-induced “swelling” and calcium capasity of the rat brain mitochondria.

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi pr-d, 142432, Chernogolovka, Moscow Region, Russian Federation

    S. O. Bachurin, D. V. Vinogradova, E. F. Shevtsova, T. V. Goreva, T. A. Epishina, A. Yu. Aksinenko & V. B. Sokolov

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  1. S. O. Bachurin
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  2. D. V. Vinogradova
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  3. E. F. Shevtsova
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  4. T. V. Goreva
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  5. T. A. Epishina
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  6. A. Yu. Aksinenko
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  7. V. B. Sokolov
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Corresponding author

Correspondence to S. O. Bachurin.

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Dedicated to academician of the Russian Academy of Sciences I. P. Beletskaya on the occasion of her anniversary.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 0815–0818, March, 2013.

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Bachurin, S.O., Vinogradova, D.V., Shevtsova, E.F. et al. Modification of gamma-carbolines with N-substituted propionamides as a new approach to mitoprotective agents. Russ Chem Bull 62, 816–819 (2013). https://doi.org/10.1007/s11172-013-0110-5

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  • DOI: https://doi.org/10.1007/s11172-013-0110-5

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