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Synthesis, structure, antioxidation, and DNA-binding studies of a binuclear ytterbium(III) complex with bis(N-salicylidene)-3-oxapentane-1,5-diamine

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Abstract

A new complex of ytterbium(III) nitrate with bis(N-salicylidene)-3-oxapentane-1,5-diamine (H2L), with the composition Yb2(L)2(NO3)2·2H2O, was synthesized and characterized by physic-chemical and spectroscopic methods. The crystal structure of the ytterbium(III) complex has been determined by single-crystal X-ray diffraction. It reveals a centrosymmetric binuclear neutral entity where Yb(III) metal centers are bridged by two phenoxo oxygen atoms. Electronic absorption titration spectra, ethidium bromide displacement experiments, and viscosity measurements indicate that both the ligand and the Yb(III) complex can bind calf thymus DNA, presumably via a groove binding mechanism. Furthermore, the antioxidant activities of the Yb(III) complex were determined by a superoxide and hydroxyl radical scavenging method in vitro, which indicates that it is a scavenger for OH and O2 − radicals.

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Acknowledgments

The present research was supported by the National Natural Science Foundation of China (Grant No. 21367017), the Fundamental Research Funds for the Gansu Province Universities (212086), National Natural Science Foundation of Gansu Province (Grant no. 1212RJZA037), and ‘Qing Lan’ Talent Engineering Funds for Lanzhou Jiaotong University.

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Authors and Affiliations

  1. School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, 730070, People’s Republic of China

    Huilu Wu, Guolong Pan, Yuchen Bai, Hua Wang, Jin Kong, Furong Shi, Yanhui Zhang & Xiaoli Wang

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  1. Huilu Wu
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  2. Guolong Pan
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  3. Yuchen Bai
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  4. Hua Wang
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  7. Yanhui Zhang
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  8. Xiaoli Wang
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Correspondence to Huilu Wu.

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Wu, H., Pan, G., Bai, Y. et al. Synthesis, structure, antioxidation, and DNA-binding studies of a binuclear ytterbium(III) complex with bis(N-salicylidene)-3-oxapentane-1,5-diamine. Res Chem Intermed 41, 3375–3388 (2015). https://doi.org/10.1007/s11164-013-1440-5

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