Abstract
Case Acyclovir is a widely administered medication for viral infection but is well known for its nephrotoxicity. To date, few studies regarding the safety of alternative antiviral agents have been reported. This study reports the case of a patient with renal dysfunction who suffers from acute herpes zoster (shingles) on her back. While renal function deteriorated with the use of acyclovir, the patient’s symptoms improved and baseline renal function recovered when she was treated with famciclovir. Conclusions Famciclovir could be taken as a first-line antiviral agent for patients with acute renal failure.
References
Sacks SL. The role of oral acyclovir in the management of genital herpes simplex. CMAJ. 1987;136(7):701–7.
Brigden D, Rosling AE, Woods NC. Renal function after acyclovir intravenous injection. Am J Med. 1982;73(1A):182–5.
Sawyer MH, Webb DE, Balow JE, Straus SE. Acyclovir-induced renal failure. Clinical course and histology. Am J Med. 1988;84(6):1067–71.
Fletcher C, Bean B. Evaluation of oral acyclovir therapy. Drug Intell Clin Pharm. 1985;19(7–8):518–24.
Perazella MA. Crystal-induced acute renal failure. Am J Med. 1999;106(4):459–65.
Htwe TH, Bergman S, Koirala J. Famciclovir substitution for patients with acyclovir-associated renal toxicity. J Infect. 2008;57(3):266–8.
Yavuz BB, Cankurtaran M, Halil M, Dagli N, Kirkpantur A. Renal dysfunction after oral acyclovir treatment in a geriatric woman: a case report. Scand J Infect Dis. 2005;37(8):611–3.
Sodhi PK, Ratan SK. A case of chronic renal dysfunction following treatment with oral acyclovir. Scand J Infect Dis. 2003;35(10):770–2.
Johnson GL, Limon L, Trikha G, Wall H. Acute renal failure and neurotoxicity following oral acyclovir. Ann Pharmacother. 1994;28(4):460–3.
Niibori D, Fujisawa M, Matsuzaki M. Severe central nervous system symptoms following oral administration of acyclovir in a patient with chronic renal failure: a case report. Hinyokika Kiyo. 1993;39(5):459–61.
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Yoon, H., Rhew, K.Y. Famciclovir as an antiviral agent for a patient with acute renal failure. Int J Clin Pharm 35, 173–175 (2013). https://doi.org/10.1007/s11096-012-9737-9
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DOI: https://doi.org/10.1007/s11096-012-9737-9