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Microstructural Elucidation of Self-Emulsifying System: Effect of Chemical Structure

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Abstract

Purpose

Self-emulsifying systems (SES) emulsify spontaneously to produce fine oil-in-water emulsion when introduced into aqueous phase. The self-emulsification process plays an important role during formation of emulsion. The objective of current work was to understand and explore the inner structuration of SES through controlled hydration and further to study the influence of additive on the same which ultimately governs performance of final formulation in terms of droplet size.

Methods

Droplet size of final formulations containing structural analogues of ibuprofen was determined. Microstructural properties of intermediate hydrated regimes of SES were investigated using techniques such as small angle X-ray scattering, differential scanning calorimetry and rheology.

Results

The current work established inverse relationship between droplet size of the formulations containing structural analogues of ibuprofen and their Log P values. Microstructural analysis of intermediate hydrated regimes of the prepared samples showed formation of local lamellar structure. Structural analogues of ibuprofen significantly altered microstructure of lamellae which was well correlated with the droplet size of final formulations. In vitro drug release study showed increase in dissolution rate of lipophillic drugs when formulated as SES.

Conclusion

The current work emphasizes the fact that tailor-made formulations can be prepared by controlling the properties of intermediate regimes.

Techniques used for Microstructural Elucidation of Self-Emulsifying System.

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ACKNOWLEDGMENTS & DISCLOSURES

The authors thank Dr. Guruswamy Kumaraswamy, Scientist, Polymer Chemistry, National Chemical Laboratory for providing facility of Small Angle X ray Scattering and for extending his cooperation in SAXS data analysis and discussion.

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Authors and Affiliations

  1. Dept. of Pharmaceutics, Bharati Vidyapeeth University Poona College of Pharmacy, Erandwane, Pune, 411 038, Maharashtra, India

    Sharvil S. Patil & Kakasaheb R. Mahadik

  2. Polymer Science and Engineering Division, National Chemical Laboratory, Pune, 411 008, India

    Sharvil S. Patil, Edakkal Venugopal & Suresh Bhat

  3. Centre for Pharmaceutical Engineering Science, University of Bradford, West Yorkshire, Bradford, BD7 1DP, UK

    Anant R. Paradkar

Authors
  1. Sharvil S. Patil
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  2. Edakkal Venugopal
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  3. Suresh Bhat
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  4. Kakasaheb R. Mahadik
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  5. Anant R. Paradkar
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Corresponding authors

Correspondence to Kakasaheb R. Mahadik or Anant R. Paradkar.

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Patil, S.S., Venugopal, E., Bhat, S. et al. Microstructural Elucidation of Self-Emulsifying System: Effect of Chemical Structure. Pharm Res 29, 2180–2188 (2012). https://doi.org/10.1007/s11095-012-0746-0

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  • DOI: https://doi.org/10.1007/s11095-012-0746-0

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