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Synthesis and Antimicrobial Activity of 4-Hydroxy-2-[5-Nitrofuran(Thien)-2-Yl]-6h-1,3-Oxazin-6-Ones

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Pharmaceutical Chemistry Journal Aims and scope

A series of new 4-hydroxy-6H-oxazin-6-ones containing 2-(5-nitrofuranyl) and 2-(5-nitrothienyl) moieties were obtained. New nitrofuran and thiophene derivatives were synthesized by reacting these oxazines with mono- (EtOH) and dinucleophiles (phenylhydrazine). It was established that the synthesized compounds possessed pronounced bactericidal activity against Staphylococcus aureus and, in some cases, Escherichia coli strains.

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Authors and Affiliations

  1. St. Petersburg State Chemical Pharmaceutical Academy, 14/A Ul. Prof. Popova, St. Petersburg, 197376, Russia

    N. M. Chernov, A. S. Koshevenko, I. P. Yakovlev, E. P. Anan’eva, G. V. Ksenofontova & A. E. Shchegolev

Authors
  1. N. M. Chernov
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  2. A. S. Koshevenko
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  3. I. P. Yakovlev
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  4. E. P. Anan’eva
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  5. G. V. Ksenofontova
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  6. A. E. Shchegolev
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Corresponding author

Correspondence to N. M. Chernov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 8, pp. 12 – 15, August, 2017.

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Chernov, N.M., Koshevenko, A.S., Yakovlev, I.P. et al. Synthesis and Antimicrobial Activity of 4-Hydroxy-2-[5-Nitrofuran(Thien)-2-Yl]-6h-1,3-Oxazin-6-Ones. Pharm Chem J 51, 644–647 (2017). https://doi.org/10.1007/s11094-017-1668-2

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  • DOI: https://doi.org/10.1007/s11094-017-1668-2

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