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Synthesis and Antiarrhythmic Activity of 1-Benzyl-3,3-Dialkyl-3,4-Dihydroisoquinoline Chlorides

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Cyclocondensation of dialkylbenzylcarbinols with benzylcyanides was used to synthesize 1-benzyl-3,3-dialkyl-3,4-dihydroisoquinolines. The hydrochlorides of the compounds synthesized here were tested for antiarrhythmic activity in a calcium chloride model. The maximum antiarrhythmic index (AI) was found with isoquinolines with cycloalkanone fragments such as cyclopentanone and cyclohexanone in position 3, which had AI values of 15.5 and 16.3, three times the corresponding value for lidocaine.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, Perm, Russia

    A. G. Mikhailovskii, O. V. Gashkova, I. P. Rudakova & D. A. Peretyagin

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  1. A. G. Mikhailovskii
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  2. O. V. Gashkova
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  3. I. P. Rudakova
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  4. D. A. Peretyagin
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Correspondence to A. G. Mikhailovskii.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 7, pp. 25 – 27, July, 2017.

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Mikhailovskii, A.G., Gashkova, O.V., Rudakova, I.P. et al. Synthesis and Antiarrhythmic Activity of 1-Benzyl-3,3-Dialkyl-3,4-Dihydroisoquinoline Chlorides. Pharm Chem J 51, 546–549 (2017). https://doi.org/10.1007/s11094-017-1651-y

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  • DOI: https://doi.org/10.1007/s11094-017-1651-y

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