Alkylation of 6-methyl-1-(thietan-3-yl)pyrimidine-2,4(1H,3H)-dione with chloroacetanilides yielded N-acetanilide derivatives. Interaction of 2-(4-methyl-2,6-dioxo-3-thietan-3-yl-3,6-dihydropyrimidin-1(2H)acetohydrazide with carbonyl compounds was used to synthesize arylaldehyde and ketone N-acetylhydrazones. The antimicrobial and antifungal activities of the compounds synthesized here were studied.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 9, pp. 28 – 31, September, 2015.
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Meshcheryakova, S.A., Kataev, V.A., Fattakhova, I.Y. et al. Synthesis and Antimicrobial Activity of Thietanylpyrimidin-2,4(1H,3H)-Dione Acetanilides and Acetylhydrazones. Pharm Chem J 49, 598–601 (2015). https://doi.org/10.1007/s11094-015-1336-3
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DOI: https://doi.org/10.1007/s11094-015-1336-3