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Effect of Native Humic Acids from Tomsk Region Lowland Peat on Mitochrondrial Oxidative Phosphorylation Under Hypoxic Conditions

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Peat humic acids (PHAs) were found under experimental normobaric hypoxia with hypercapnia to normalize the activities of succinate- and NAD-dependent energy-production processes and to prevent disconnection of oxidative phosphorylation in mouse cerebral and hepatic mitochondria. The antihypoxic activity of PHAs was comparable with that of the reference antihypoxant dihydroquercetin in mouse brain and exceeded it in liver. The observed normalization by PHAs of oxidative phosphorylation in cerebral and hepatic mitochondria was probably related to their protective properties that prevented free-radical damage of cells and organelles under hypoxic conditions.

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Authors and Affiliations

  1. Siberian State Medical University, Tomsk, 634050, Russia

    M. V. Belousov, M. V. Zykova, K. Yu. Vasil’ev & M. S. Yusubov

  2. Tomsk National Research Polytechnic University, Tomsk, 634050, Russia

    R. R. Akhmedzhanov & M. S. Yusubov

Authors
  1. M. V. Belousov
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  2. R. R. Akhmedzhanov
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  3. M. V. Zykova
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  4. K. Yu. Vasil’ev
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  5. M. S. Yusubov
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 4, pp. 39 – 43, April, 2015.

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Belousov, M.V., Akhmedzhanov, R.R., Zykova, M.V. et al. Effect of Native Humic Acids from Tomsk Region Lowland Peat on Mitochrondrial Oxidative Phosphorylation Under Hypoxic Conditions. Pharm Chem J 49, 250–253 (2015). https://doi.org/10.1007/s11094-015-1265-1

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  • DOI: https://doi.org/10.1007/s11094-015-1265-1

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