Academician N. P. Kravkov (1865 – 1924), the founder of Russian pharmacology, was the first scientist in Russia who studied the problem of how the action of drugs depends on their chemical structure. Using the method of isolated organs of animals, he established a number of correlations between the variation of pharmacological effects such as the strength and character of action and toxicity in series of hypnotics, narcotic analgesics, cardiac glycosides, and alcohols as their chemical structure was made more complex by adding various radicals or by increasing the number of carbon atoms. At present, N. P. Kravkov’s works in this direction are still used as the theoretical basis for developing new drugs.
Similar content being viewed by others
References
D. G. Uzbekova, The Kravkovs, Two Generations of Scientists from Ryazan [in Russian], Veche, Moscow, 2014, pp. 25 – 70.
A. N. Kuznetsov, Kravkov, Mediagiz, Moscow, 1948, pp. 59 – 60.
N. P. Kravkov, Russ. Vrach, No. 1, 1 – 6 (1914).
N. P. Kravkov, Vrach, No. 46 – 47, 1305 – 1344 (1898).
A. V. Semichev, Russ. Vrach, No. 1, 17 – 18 (1910).
S. P. Fedorov, Vrach. Gaz., No. 20, 2478 – 2480 (1929).
N. P. Kravkov, Russ. Vrach, No. 48, 1697 – 1698 (1903).
N. P. Kravkov, Russ. Vrach, No. 12, 405 – 411 (1910).
N. P. Kravkov, Principles of Pharmacology [in Russian], Izd. K. P. Rikkera, St. Petersburg, 1911, p. 17.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 2, pp. 55 – 56, February, 2015.
Rights and permissions
About this article
Cite this article
Uzbekova, D.G. The Importance of Academician N. P. Kravkov’s Studies of the Relationship Between Drug Action and Chemical Structure (On The 150TH Birthday of Academician N. P. Kravkov). Pharm Chem J 49, 139–140 (2015). https://doi.org/10.1007/s11094-015-1237-5
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-015-1237-5