A series of 2-(3-methyl-6-methoxy-7-ethoxy-3,4-dihydroisoquinolyl-1)ethanoic acid amides were synthesized via cyclocondensation of O-ethylated eugenol with cyanoacetic acid amides. Hydrochlorides of the synthesized compounds were shown to exhibit anthelmintic activity. The unsubstituted amide was the most active and exhibited activity equal to that of levamisole and significantly greater than that of pyrantel. The insecticidal activity of the synthesized compounds was inferior to that of imidacloprid.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 10, pp. 33 – 36, October, 2014.
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Surikova, O.V., Mikhailovskii, A.G., Syropyatov, B.Y. et al. Synthesis, Anthelmintic, and Insecticidal Activity of 2-(3-Methyl-6-Methoxy-7-Ethoxy-3,4-Dihydroisoquinolyl-1)Ethanoic Acid Amides. Pharm Chem J 48, 665–668 (2015). https://doi.org/10.1007/s11094-015-1166-3
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DOI: https://doi.org/10.1007/s11094-015-1166-3