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Synthesis and Biological Activity of 4-Chloro-1H-Imidazole-5-Carbaldehyde Thiosemicarbazones

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Pharmaceutical Chemistry Journal Aims and scope

A series of thiosemicarbazones, the structures of which were established by IR and PMR spectroscopy and mass spectrometry, were synthesized by condensation of 4-chloro-1H-imidazole-5-carbaldehydes with thiosemicarbazide. Some of the synthesized compounds were found to exhibit high inhibitory activity with respect to M. tuberculosis strains that was 1.5 times more effective than the reference drug isoniazid. Astudy of the antimicrobial activity of the synthesized thiosemicarbazones showed that their fungistatic properties were more pronounced than their bacteriostatic properties.

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Authors and Affiliations

  1. Bukovinian State Medical University, Chernivtsi, 58000, Ukraine

    V. A. Chornous, A. N. Grozav & L. D. Todoriko

  2. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 02660, Kiev, Ukraine

    M. V. Vovk

Authors
  1. V. A. Chornous
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  2. A. N. Grozav
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  3. L. D. Todoriko
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  4. M. V. Vovk
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Corresponding author

Correspondence to V. A. Chornous.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 47, No. 10, pp. 19 – 21, October, 2013.

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Chornous, V.A., Grozav, A.N., Todoriko, L.D. et al. Synthesis and Biological Activity of 4-Chloro-1H-Imidazole-5-Carbaldehyde Thiosemicarbazones. Pharm Chem J 47, 524–526 (2014). https://doi.org/10.1007/s11094-014-0996-8

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  • DOI: https://doi.org/10.1007/s11094-014-0996-8

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