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Synthesis and Biological Activity of N-[3-(4-Substituted Phenyl)-3-hydroxypropyl]valines and -Tryptophans, and 3-{[3-Hydroxy-3-(4-substituted phenyl)propyl]amino}-3-phenylpropanoic Acids

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Pharmaceutical Chemistry Journal Aims and scope

Reduction of N-[β-(4-substituted benzoyl)ethyl]amino acids with sodium borohydride yielded arylaliphatic aminopropanols containing amino acid fragments – N-[3-(4-substituted phenyl)-3-hydroxypropyl]valines,-tryptophans, and 3-{[3-hydroxy-3-(4-substituted phenyl)propyl]amino}-3-phenylpropanoic acids. Studies of the biological activities of these compounds showed that some had anti-inflammatory and anticonvulsive activities.

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Authors and Affiliations

  1. Organic and Pharmaceutical Chemistry Science and Technology Center, National Academy of Sciences of the Republic of Armenia, A. L. Mndzhoyan Institute of Fine Organic Chemistry, Erevan, Armenia

    A. G. Agababyan, G. A. Gevorgyan, A. P. Avakyan, A. E. Tumadzhyan & R. G. Paronikyan

  2. Molecular Structure Study Center, National Academy of Sciences of the Republic of Armenia, Yerevan, Armenia

    G. A. Panosyan

Authors
  1. A. G. Agababyan
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  2. G. A. Gevorgyan
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  3. A. P. Avakyan
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  4. A. E. Tumadzhyan
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  5. R. G. Paronikyan
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  6. G. A. Panosyan
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Corresponding author

Correspondence to G. A. Gevorgyan.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 47, No. 7, pp. 22 – 25, July, 2013.

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Agababyan, A.G., Gevorgyan, G.A., Avakyan, A.P. et al. Synthesis and Biological Activity of N-[3-(4-Substituted Phenyl)-3-hydroxypropyl]valines and -Tryptophans, and 3-{[3-Hydroxy-3-(4-substituted phenyl)propyl]amino}-3-phenylpropanoic Acids. Pharm Chem J 47, 361–365 (2013). https://doi.org/10.1007/s11094-013-0959-5

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  • DOI: https://doi.org/10.1007/s11094-013-0959-5

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