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Biopharmaceutical assessment of a polycomplex matrix system based on carbomer 940 and Eudragit® EPO for colon-specific drug delivery

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The biopharmaceutical properties of a new drug carrier based on an interpolyelectrolyte complex (IPEC) between Carbomer 940 and Eudragit® EPO have been studied in the form of a polycomplex matrix system (PMS) intended to be a potential carrier for peroral drug delivery systems. The release profiles of diclofenac sodium from the proposed PMS and Voltaren® retard in model gastroitestial tract medium belong to the intestine-soluble and sustained-release types, respectively. Evaluation of the pharmacokinetic parameters of the PMS revealed a close in vitro/in vivo correlation. The proposed PMS, in contrast to the parent drug, provides targeted drug delivery to the colon region and is comparable with Voltaren® retard with respect to the bioavailability and the main pharmacokinetic parameters.

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Acknowledgments

The work was performed under the auspices of the Federal Targeted Program “Science and Science-Pedagogical Departments of Innovation Russia for 2009 – 2013” (State Contract No. 02.740.11.0775).

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Authors and Affiliations

  1. Kazan State Medical University, Kazan, Tatarstan, Russia

    R. I. Mustafin, T. V. Kabanova, I. I. Semina, A. V. Bukhovets, V. R. Garipova, E. V. Shilovskaya, Sh. F. Nasibullin, A. Yu. Sitenkov & R. R. Kazakova

  2. Scientific Center for Biomedical Technologies, State Research Institute of Medicinal and Aromatic Plants, Moscow, Russia

    V. A. Kemenova

Authors
  1. R. I. Mustafin
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  2. T. V. Kabanova
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  3. I. I. Semina
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  4. A. V. Bukhovets
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  5. V. R. Garipova
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  6. E. V. Shilovskaya
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  7. Sh. F. Nasibullin
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  8. A. Yu. Sitenkov
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  9. R. R. Kazakova
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  10. V. A. Kemenova
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Corresponding author

Correspondence to R. I. Mustafin.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 8, pp. 41 – 44, August, 2011.

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Mustafin, R.I., Kabanova, T.V., Semina, I.I. et al. Biopharmaceutical assessment of a polycomplex matrix system based on carbomer 940 and Eudragit® EPO for colon-specific drug delivery. Pharm Chem J 45, 491–494 (2011). https://doi.org/10.1007/s11094-011-0662-3

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  • DOI: https://doi.org/10.1007/s11094-011-0662-3

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