Taking into account the structure—activity relationship established previously for imidazobenzimidazole derivatives with high hemorheological activity, several new 9-R-2-halogenophenyl-substituted imidazo[1,2-a]benzimidazoles with C2 fluoro-, chloro-, dichloro-, or bromo-phenyl radicals have been synthesized. All substances were tested in vitro for various types of pharmacological activity characteristic of this class of drugs including hemorheological, antiplatelet, antiarrhythmic, antioxidant; 5-HT2-, 5-HT3-, P2Y1-, and H1-antagonist; and κ-opioid-agonist.
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The work was performed with financial support from the Russian Foundation for Basic Research (Grant No. 07-04-00424).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 44, No. 7, pp. 7 – 13, July, 2010.
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Anisimova, V.A., Spasov, A.A., Tolpygin, I.E. et al. Synthesis and pharmacological activity of 9-R-2-halogenophenylimidazo[1,2-a]benzimidazoles. Pharm Chem J 44, 345–351 (2010). https://doi.org/10.1007/s11094-010-0465-y
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DOI: https://doi.org/10.1007/s11094-010-0465-y