The effect of solid dispersions (SDs) on the solubility of parmidin has been studied by comparing the solubility of parmidin, its SDs, and physical mixtures with polyethyleneglycol-1500, polyvinylpyrrolidone-10000, and β-cyclodextrin. It is established that the formulation of SDs increases the solubility and the dissolution rate of parmidin. Data obtained using a complex of physical and chemical methods suggest that improvement of the drug release from SDs is due to the solubilization and the formation of a colloidal-dispersion state of the given substance.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 8, pp. 45 – 49, August, 2009.
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Khabriev, R.U., Popkov, V.A., Reshetnyak, V.Y. et al. Increasing the solubility of an angioprotector by the method of solid dispersions. Pharm Chem J 43, 472–476 (2009). https://doi.org/10.1007/s11094-009-0326-8
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DOI: https://doi.org/10.1007/s11094-009-0326-8