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Synthesis and antimicrobial activity of 2,4-dioxothiazolidine-5-acetic acid amides

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Abstract

The antimicrobial activity of 2,4-dioxothiazolidine-5-acetic acid amides and their 3-substituted analogs has been studied. The initial acid was obtained by an effective one-pot method using the reaction of thiourea with maleic anhydride in hydrochloric acid. The maximum anti-staphylococcal activity was exhibited by N-[5-(R-benzyl)thiazol-2-yl]-2-(2,4-dioxothiazolidin-5-yl)acetamides.

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Authors and Affiliations

  1. Lviv National Medical University, Lviv, Ukraine

    B. S. Zimenkovskii & R. B. Lesyk

  2. Ivano-Frankivsk State Medical Academy, Ivano-Frankivsk, Ukraine

    R. V. Kutsyk & T. I. Klyufinska

  3. Lviv National University, Lviv, Ukraine

    V. S. Matyichuk & N. D. Obushak

Authors
  1. B. S. Zimenkovskii
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  2. R. V. Kutsyk
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  3. R. B. Lesyk
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  4. V. S. Matyichuk
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  5. N. D. Obushak
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  6. T. I. Klyufinska
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 6, pp. 13–16, June, 2006.

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Zimenkovskii, B.S., Kutsyk, R.V., Lesyk, R.B. et al. Synthesis and antimicrobial activity of 2,4-dioxothiazolidine-5-acetic acid amides. Pharm Chem J 40, 303–306 (2006). https://doi.org/10.1007/s11094-006-0115-6

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  • DOI: https://doi.org/10.1007/s11094-006-0115-6

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