Abstract
Synthesis of anti-HIV nucleoside lipophilic derivatives with diol compounds in which two antiviral pharmacophore residues are linked by a single hydrophobic fragment is described. It is suggested to use 2,3,4,5-tetra-O-benzyl-D, L-iditol and 1,12-dodecanediol as hydrophobic transport systems. Succinic and phosphodiester fragments were used for binding molecular units in the target conjugates.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 5, pp. 41–45, May, 2006.
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Tuchnaya, O.A., Elizarova, S.N., Sharikova, S.A. et al. Synthesis of anti-HIV nucleoside conjugates with lipophilic diol compounds. Pharm Chem J 40, 276–280 (2006). https://doi.org/10.1007/s11094-006-0108-5
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DOI: https://doi.org/10.1007/s11094-006-0108-5