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Synthesis and Antiarrhythmic Activity of 5-Amino-exo-3-azatricyclo[5.2.1.02,6]decan-4-one

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Abstract

Exo-2-amino-exo-3-aminomethylbicyclo[2.2.1]heptane (I) and 5-amino-exo-3-azatricyclo[5.2.1.02,6]decan-4-one (II) were synthesized and characterized with respect to antiarrhythmic activity. Compound II exhibited antiarrhythmic activity with ED50 = 0.28 and 0.33 mg/kg on the aconitine and calcium chloride models of arrhythmia, respectively. Compound I did not show antiarrhythmic activity and exhibited acute toxicity corresponding to LD50 = 450 mg/kg.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, Ufa, Bashkortostan, Russia

    V. A. Gorpinchenko, E. A. Yatsynich, D. V. Petrov, L. T. Karachurina, R. Yu. Hisamutdinova, N. Zh. Baschenko, V. A. Dokichev & M. S. Yunusov

  2. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

    Yu. V. Tomilov & O. M. Nefedov

Authors
  1. V. A. Gorpinchenko
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  2. E. A. Yatsynich
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  3. D. V. Petrov
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  4. L. T. Karachurina
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  5. R. Yu. Hisamutdinova
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  6. N. Zh. Baschenko
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  7. V. A. Dokichev
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  8. Yu. V. Tomilov
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  9. M. S. Yunusov
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  10. O. M. Nefedov
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 6, pp. 9 – 11, June, 2005.

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Gorpinchenko, V.A., Yatsynich, E.A., Petrov, D.V. et al. Synthesis and Antiarrhythmic Activity of 5-Amino-exo-3-azatricyclo[5.2.1.02,6]decan-4-one. Pharm Chem J 39, 289–291 (2005). https://doi.org/10.1007/s11094-005-0135-7

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  • DOI: https://doi.org/10.1007/s11094-005-0135-7

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