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Adult Chronic Kidney Disease: Neurocognition in Chronic Renal Failure

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Abstract

In recent years there has been a keen interest in the neurocognitive sequelae of renal failure and subsequent end-stage renal disease given its increasing prevalence and incidence. This review article summarizes the relevant information on cognitive functioning in chronic kidney disease in adults before the initiation of dialysis, after the initiation of dialysis, and after renal transplantation. In general, compared to pre-dialysis, there is an improvement in cognitive function after the institution of dialysis and further improvement after renal transplantation. Throughout the paper an attempt is made to highlight the importance of considering disease related variables in the neuropsychological assessment of individuals with chronic kidney disease. The paper concludes with a discussion of future avenues of research.

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Acknowledgement

The first author would like to thank Dr. Neil Pliskin for reading and commenting on a previous version of the manuscript.

Disclosure

The authors do not have any conflicts of interest to disclose. No funding was procured for the production of this manuscript.

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Author notes

  1. Nikhil S. Koushik

    Present address: Alberta Children’s Hospital, Calgary, Alberta, Canada

  2. Steven F. McArthur

    Present address: Psychology Section, John D. Dingell VA Medical Center, Detroit, MI, USA

Authors and Affiliations

  1. Department of Psychology, The University of Windsor, Windsor, Ontario, Canada

    Nikhil S. Koushik & Anne D. Baird

  2. Department of Psychiatry and Behavioural Neurosciences, Wayne State University, Detroit, MI, USA

    Steven F. McArthur

  3. Neurosciences, Alberta Children’s Hospital, 2888 Shaganappi Trail NW, Calgary, Alberta, Canada, T3B 6A8

    Nikhil S. Koushik

Authors
  1. Nikhil S. Koushik
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  2. Steven F. McArthur
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  3. Anne D. Baird
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Correspondence to Nikhil S. Koushik.

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Koushik, N.S., McArthur, S.F. & Baird, A.D. Adult Chronic Kidney Disease: Neurocognition in Chronic Renal Failure. Neuropsychol Rev 20, 33–51 (2010). https://doi.org/10.1007/s11065-009-9110-5

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  • DOI: https://doi.org/10.1007/s11065-009-9110-5

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