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Restraint Stress Potentiated Morphine Sensitization: Involvement of Dopamine Receptors within the Nucleus Accumbens

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Abstract

Sensitization to psychostimulant drugs, as well as morphine, subjected to cross-sensitization with stress. The development of morphine sensitization is associated with enhancements in dopamine overflow in the Nucleus accumbens (NAc). This study aimed to examine the role of accumbal D1/D2-like dopamine receptors in restraint stress (RS) induced sensitization to morphine antinociceptive effects. Adult male Wistar rats weighing 220–250 g underwent stereotaxic surgery. Two stainless steel guide cannulae were bilaterally implanted, 1 mm above the NAc injection site. Different solutions of SCH-23390, as a D1-like receptor antagonist or sulpiride, as a D2-like receptor antagonist, were microinjected into the NAc five min before exposure to RS. Restraint stress lasted for 3 h, 10 min after RS termination; animals received a subcutaneous injection of morphine (1 mg/kg) for 3 consecutive days. The procedure was followed by a 5-day drug and/or stress-free period. After that, on the 9th day, the nociceptive response was evaluated by the tail-flick test. The results revealed that intra-NAc administration of D1/D2-like dopamine receptor antagonists, SCH-23390 or sulpiride, respectively, blocked morphine sensitization-induced by RS and morphine co-administration in rats for three consecutive days. This work provides new insight into the determinant role of accumbal dopamine receptors in morphine sensitization produced by RS-morphine co-administration.

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Acknowledgements

The Vice-Chancellor for Research & Technology of Shahid Beheshti University of Medical Sciences supported this work (Grant No. 98-21484-1398/12/20). Also, the authors would like to appreciate the Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, for their cooperation in carrying out this study.

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  1. Faculty of Veterinary Medicine, Department of Physiology, University of Tehran, Tehran, Iran

    Elham Charmchi, Golnaz Faramarzi & Morteza Zendehdel

  2. Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mina Rashvand & Abbas Haghparast

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  1. Elham Charmchi
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AH: Conceptualization, Methodology, Writing-Reviewing, and Editing. EC: Data curation, Data analysis, Writing-Original draft preparation. GF: Writing-Original draft preparation. MR: Writing-Original draft preparation, Writing-Reviewing, and Editing. MZ: Supervision. All authors critically reviewed content and approved the final version for publication.

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Charmchi, E., Faramarzi, G., Rashvand, M. et al. Restraint Stress Potentiated Morphine Sensitization: Involvement of Dopamine Receptors within the Nucleus Accumbens. Neurochem Res 46, 648–659 (2021). https://doi.org/10.1007/s11064-020-03199-5

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