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Linalool Inhibits LPS-Induced Inflammation in BV2 Microglia Cells by Activating Nrf2

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Abstract

Linalool, a natural compound of the essential oils, has been reported to have anti-inflammatory effects. This study aimed to investigate the anti-inflammatory effects and mechanism of linalool in LPS-stimulated BV2 microglia cells. BV2 microglia cells were stimulated with LPS in the presence or absence of linalool. The production of inflammatory mediators TNF-α, IL-1β, NO, and PGE2 as well as Nrf2, HO-1 expression were detected. Our results showed that linalool inhibited LPS-induced TNF-α, IL-1β, NO, and PGE2 production in a dose-dependent manner. Linalool also inhibited LPS-induced NF-κB activation. Treatment of linalool induced nuclear translocation of Nrf2 and expression of HO-1. In addition, our results showed that the anti-inflammatory effect of linalool was attenuated by transfection with Nrf2 siRNA. In conclusion, these results suggested that linalool inhibits LPS-induced inflammation in BV2 microglia cells by activating Nrf2/HO-1 signaling pathway.

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All authors declare that they have no conflict of interest.

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    Authors and Affiliations

    1. Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China

      Yang Li, Fenggang Zhou, Qingsong Li, Zhichao Wu & Yongri Zheng

    2. Department of Neorology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China

      Ou Lv

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    1. Yang Li
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    2. Ou Lv
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    3. Fenggang Zhou
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    4. Qingsong Li
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    Correspondence to Fenggang Zhou.

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    Yang Li and Ou Lv have contributed equally to this article.

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    Li, Y., Lv, O., Zhou, F. et al. Linalool Inhibits LPS-Induced Inflammation in BV2 Microglia Cells by Activating Nrf2. Neurochem Res 40, 1520–1525 (2015). https://doi.org/10.1007/s11064-015-1629-7

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    • DOI: https://doi.org/10.1007/s11064-015-1629-7

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