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Association Between Na+,K+-ATPase Activity and the Vulnerability/Resilience to Mood Disorders induced by Early Life Experience

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Abstract

There is increasing evidence that early life events can influence neurodevelopment and later susceptibility to disease. Chronic variable stress (CVS) has been used as a model of depression. The objective of this study was to evaluate the interaction between early experience and vulnerability to chronic variable stress in adulthood, analyzing emotional, metabolic and neurochemical aspects related to depression. Pups were (1) handled (10 min/day) or (2) left undisturbed from day 1 to 10 after birth. When the animals reached adulthood, the groups were subdivided and the rats were submitted or not to CVS, which consisted of daily exposure to different stressors for 40 days, followed by a period of behavioral tasks, biochemical (plasma corticosterone and insulin sensitivity) and neurochemical (Na+,K+-ATPase activity in hippocampus, amygdala and parietal cortex) measurements. Neonatally-handled rats demonstrated shorter immobility times in the forced swimming test, independently of the stress condition. There was no difference concerning basal corticosterone or insulin sensitivity between the groups. Na+,K+-ATPase activity was decreased in hippocampus and increased in the amygdala of neonatally-handled rats. CVS decreased the enzyme activity in the three structures, mainly in the non-handled group. These findings suggest that early handling increases the ability to cope with chronic variable stress in adulthood, with animals showing less susceptibility to neurochemical features associated with depression, confirming the relevance of the precocious environment to vulnerability to psychiatric conditions in adulthood.

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Authors and Affiliations

  1. PPG Neurociências, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

    Patrícia Pelufo Silveira, Aldo Bolten Lucion & Carla Dalmaz

  2. Departamento de Pediatria e Puericultura, FAMED-Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2350, Largo Eduardo Zaccaro Faraco, 90035-903, Rio Grande do Sul, Porto Alegre, Brazil

    Patrícia Pelufo Silveira

  3. Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

    Alexandra Ioppi Zugno, Emilene Barros da Silva Scherer, Cristiane Bastos Mattos, Angela T. S. Wyse & Carla Dalmaz

  4. Departamento de Fisiologia, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

    Aldo Bolten Lucion

  5. Núcleo de Estudos da Saúde da Criança e do Adolescente (NESCA), Faculdade de Medicina, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio, Rio Grande do Sul, Brazil

    Patrícia Pelufo Silveira, André Krumel Portella & Carla da Silva Benetti

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  1. Patrícia Pelufo Silveira
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  2. André Krumel Portella
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Correspondence to Patrícia Pelufo Silveira.

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Silveira, P.P., Portella, A.K., da Silva Benetti, C. et al. Association Between Na+,K+-ATPase Activity and the Vulnerability/Resilience to Mood Disorders induced by Early Life Experience. Neurochem Res 36, 2075–2082 (2011). https://doi.org/10.1007/s11064-011-0531-1

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  • DOI: https://doi.org/10.1007/s11064-011-0531-1

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