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Expression and Signaling of Formyl-Peptide Receptors in the Brain

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Abstract

The human formyl-peptide receptor (FPR) and its variants FPRL1 and FPRL2 belong to the G-protein coupled seven transmembrane receptor (GPCR) family sensitive to pertussis toxin. FPR and FPRL1 were first detected in phagocytic leukocytes, and FPRL2 was found in monocytes and in dendritic cells. The three receptors were subsequently identified in other cell types or tissues, including neuronal cells and brain, where FPR and FPRL1 play a key role in angiogenesis, cell proliferation, protection against and cell death, as well as in neuroendocrine functions. Binding of different agonists to FPRs triggers several signaling pathways, activates NFkB and STAT3 transcriptional factors and induces the accumulation of the CDK inhibitors p21waf1/cip1, p16INK4 and p27kip1. Signaling molecules, such as ERKs, JNK, PKC, p38MAPK, PLC and PLD are involved in these intracellular cascades. In this article we briefly review FPRs expression and signaling in neuronal cells.

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Acknowledgments

We are greatful to the eminent scientist Prof. Abel Lajtha for being founder and Editor in Chief of Neurochemical Research, now in its 34th year. This work was supported by grants from Ministero dell’Università e della Ricerca Scientifica e Tecnologica PRIN 2007 “Attivazione dei recettori per formil-peptidi e regolazione della NADPH ossidasi in linee cellulari tumorali umane non fagocitiche”. We thank Jean Ann Gilder (Scientific Communication srl) for text editing.

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  1. Dipartimento di Biochimica e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Via S. Pansini 5, 80131, Naples, Italy

    Fabio Cattaneo & Rosario Ammendola

  2. Dipartimento di Scienze per la Salute, Università degli Studi del Molise, Località Tappino, 86100, Campobasso, Italy

    Germano Guerra

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  1. Fabio Cattaneo
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  2. Germano Guerra
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Correspondence to Rosario Ammendola.

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Special issue article in honor of Prof. Abel Lajtha.

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Cattaneo, F., Guerra, G. & Ammendola, R. Expression and Signaling of Formyl-Peptide Receptors in the Brain. Neurochem Res 35, 2018–2026 (2010). https://doi.org/10.1007/s11064-010-0301-5

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