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Enhanced Dendritic Action Potential Backpropagation in Parvalbumin-positive Basket Cells During Sharp Wave Activity

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Abstract

In this study two-photon imaging and single cell electrophysiological measurements were carried out in PV+ hippocampal interneurons to compare the dendritic calcium dynamics of somatically evoked backpropagating action potentials (BAPs) and in vitro sharp wave oscillation (SPW) activated BAPs at different distances from the soma. In the case of 300 μm thick, non-oscillating slices, the BAP-evoked Ca2+ (BAP-Ca2+) influx propagated along the dendritic tree in a non-uniform manner and its amplitude gradually reduced when measured at more distal regions. In contrast to the evoked BAP-Ca2+s, the spontaneous SPW-induced Ca2+ influx had only a small distance-dependent decrement. Our results suggest that similarly to nicotinic acetylcholine receptor activation, synaptic activity during hippocampal SPWs increases AP backpropagation into distant dendritic segments. Bath application of Nimodipine, a specific Ca2+ channel blocker and tetrodotoxine decreased the amplitude of the somatically evoked Ca2+ influx, which suggests that L-type Ca2+ channels play an important role both during somatically evoked and SPW-induced BAPs.

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Acknowledgments

This work was supported by the grants OM-00131/2007, OM-00132/2007, GOP-1.1.1-08/1-2008-0085, NK 72959, Grant of Hungarian Academy of Sciences.

Comments

Dr. Lajtha was one of the founders of modern neurochemistry and a founding member of several journals and societies. Over the past 60 years, he has earned his reputation as a first-class scientist; editor of several books and journals, and his Handbook of Neurochemistry. But, when we asked him what pleases him most about his scientific accomplishments, he answered, and that is characteristic of him, “most rewarding was the feeling that I was helping young scientists from all over the world experience the pleasure of performing creative research.” In his life there has been no change whatsoever in his commitment to quality science. That is what he stood for, stands for, and that is what he shall remain. Neurochemical research at the bench level and collaboration with other colleagues has always been important to him. It was an additional pleasure for him to have informal contacts with foreign scientists of different cultural backgrounds. Such contacts and collaborations carried out in several laboratories have fostered many long-lasting friendships.

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Authors and Affiliations

  1. Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony str. 43, 1083, Budapest, Hungary

    Balázs Chiovini, Gergely F. Turi, Gergely Katona, Attila Kaszás, Ferenc Erdélyi, Gábor Szabó, Attila Csákányi, E. Sylvester Vizi & Balázs Rózsa

  2. Department of Clinical Neurobiology, University of Heidelberg, Heidelberg, Germany

    Hannah Monyer

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  1. Balázs Chiovini
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  2. Gergely F. Turi
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Correspondence to Balázs Rózsa.

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Special Issue: In Honor of Dr. Abel Lajtha.

Gergely Katona, E. Sylvester Vizi, Balázs Rózsa, are owners of Femtonics Ltd.

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Chiovini, B., Turi, G.F., Katona, G. et al. Enhanced Dendritic Action Potential Backpropagation in Parvalbumin-positive Basket Cells During Sharp Wave Activity. Neurochem Res 35, 2086–2095 (2010). https://doi.org/10.1007/s11064-010-0290-4

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  • DOI: https://doi.org/10.1007/s11064-010-0290-4

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