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Antioxidant-Like Effects and Protective Action of Transcranial Magnetic Stimulation in Depression Caused by Olfactory Bulbectomy

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Abstract

We studied the effects of transcranial magnetic stimulation (TMS, 60 Hz and 0.7 mT for 4 h/day for 14 days) on oxidative and cell damage caused by olfactory bulbectomy (OBX) in Wistar rats. The levels of lipid peroxidation products and caspase-3 were enhanced by OBX, whereas it prompted a reduction in reduced glutathione (GSH) content and antioxidative enzymes activities. The treatment with TMS reverted towards normality the biomarkers indicative of oxidative stress and apoptosis. In conclusion, our data show that TMS induced a protection against cell and oxidative damage induced by OBX, as well as they support the hypothesis that oxidative stress may play an important role in depression.

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Authors and Affiliations

  1. Dpto. Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Córdoba, Avda. Menéndez Pidal s/n, Córdoba, Spain

    Inmaculada Tasset, Pedro Montilla, Francisco Javier Medina & Isaac Túnez

  2. Instituto Maimónides de Investigaciones Biomédicas de Córdoba, Avda. Menéndez Pidal s/n, Córdoba, Spain

    Inmaculada Tasset & Isaac Túnez

  3. Departamento de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México, DF, Mexico

    René Drucker-Colín

  4. Dpto. de Ciencias Morfológicas, Sección de Histología, Facultad de Medicina, Universidad de Córdoba, Córdoba, Spain

    José Peña & Ignacio Jimena

  5. Servicio de Análisis Clínicos, Hospital Universitario Reina Sofía, Córdoba, Spain

    Pedro Montilla

Authors
  1. Inmaculada Tasset
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  2. René Drucker-Colín
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  5. Pedro Montilla
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  6. Francisco Javier Medina
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  7. Isaac Túnez
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Correspondence to Isaac Túnez.

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Tasset, I., Drucker-Colín, R., Peña, J. et al. Antioxidant-Like Effects and Protective Action of Transcranial Magnetic Stimulation in Depression Caused by Olfactory Bulbectomy. Neurochem Res 35, 1182–1187 (2010). https://doi.org/10.1007/s11064-010-0172-9

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  • DOI: https://doi.org/10.1007/s11064-010-0172-9

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