Abstract
In rats, object discrimination depends on the integrity of the cholinergic system, thus it could be expected that nerve growth factor (NGF) can improve the behavior in aged subjects. The interactive effect of age and cholinergic improvement was assessed behaviorally in young and aged rats. Animals were injected by infusion of NGF into the lateral ventricles and they were tested in two behavioral tasks: an object-location and an object-recognition task. Spatial and recognition memory were assessed in an open field containing five different objects. Rats were submitted to six consecutive sessions. Both age-groups showed comparable habituation of exploratory response in Session 1–4. Discrimination index (DI) was calculated to assess responses to spatial change in Session 5 and object change in Session 6. Control young and aged rats were able to discriminate between familiar and novel object, however DI was lower in aged rats. Treatment with NGF induced decline of object discrimination in both age-groups. Different results were obtained in spatial displacement test. NGF was able to improve spatial memory in aged rats, but had no effect in young controls. These data confer on NGF potential role in improving spatial but not episodic memory in aged rats.
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This research was supported by Grant No. 2 PO5A121 28 from the Ministry of Scientific Research and Information Technology of Poland to Grazyna Niewiadomska and statutory grant to the Nencki Institute. We thank Dr Pawel Boguszewski for his permission to use the software originally developed by him for behavioral analysis and Dr Gernot Riedel for his helpful comments on initial drafts of this article.
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Niewiadomska, G., Baksalerska-Pazera, M., Gasiorowska, A. et al. Nerve Growth Factor Differentially Affects Spatial and Recognition Memory in Aged Rats. Neurochem Res 31, 1481–1490 (2006). https://doi.org/10.1007/s11064-006-9209-5
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DOI: https://doi.org/10.1007/s11064-006-9209-5