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Tuberin – A New Molecular Target in Alzheimer’s Disease?

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Tuberous sclerosis complex (TSC) is a common genetic disorder in which affected individuals develop mental retardation, developmental brain defects and seizures. The TSC gene products, hamartin and tuberin, form a complex, of which tuberin is assumed to be the functional component being involved in a wide variety of different cellular processes. Here we report that tuberin protein levels are decreased in the frontal cortex of patients with Alzheimer’s disease. In addition, tuberin levels are also decreased in Down syndrome brain samples positive for β-amyloid plaques and neurofibrillary tangles. Analysis of NeuN revealed that this regulation is not a consequence of differences in the amount of postmitotic neurons. This first connection of tuberin to another common disease beside TSC stimulates new approaches to investigate the molecular development and to establish new therapeutic strategies.

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Authors and Affiliations

  1. Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, General Hospital, 1090, Währinger Gürtel 18-20, Vienna, 1090, Austria, Austria

    Rosa Ferrando-Miguel, Margit Rosner, Angelika Freilinger & Markus Hengstschläger

  2. Department of Pediatrics, Medical University of Vienna, General Hospital, 1090, Vienna, Austria

    Rosa Ferrando-Miguel & Gert Lubec

Authors
  1. Rosa Ferrando-Miguel
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  2. Margit Rosner
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  3. Angelika Freilinger
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  4. Gert Lubec
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  5. Markus Hengstschläger
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Correspondence to Rosa Ferrando-Miguel.

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Ferrando-Miguel, R., Rosner, M., Freilinger, A. et al. Tuberin – A New Molecular Target in Alzheimer’s Disease?. Neurochem Res 30, 1413–1419 (2005). https://doi.org/10.1007/s11064-005-8511-y

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  • DOI: https://doi.org/10.1007/s11064-005-8511-y

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