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Effects of Neural Crest-Derived Multipotent Stem Cells on Regeneration of an Injured Peripheral Nerve in Mice

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Neurophysiology Aims and scope

We studied the effect of transplantation of neural crest-derived multipotent stem cells (NC-MSCs) obtained from vibrissa germs on regeneration of the injured (transected) sciatic nerve in adult mice (strain FVB). After transplantation of the cells into the injured region, regeneration of the severed nerve was intensified, as compared with that in mice with no implantation. The intensity of vascularization and renewal of the endoneurium also increased. The density of nerve fibers in the distal part of the injured nerve in mice after transplantation of NC-MSCs (10522.8 ± 1044.0 mm–2) was significantly higher than that in mice with nerve injury but without transplantation (8409.5 ± 739.5 mm–2). Possible mechanisms of acceleration of regeneration of the injured peripheral nerve under conditions of transplantation of stem cells are discussed.

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Authors and Affiliations

  1. State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine

    R. G. Vasyliev, A. E. Rodnichenko, A. S. Demidchouk, I. F. Labunets & G. M. Butenko

  2. Bogomolets National Medical University, Ministry of Public Health of Ukraine, Kyiv, Ukraine

    S. N. Shamalo, A. S. Demidchouk & Yu. B. Chaikovskii

Authors
  1. R. G. Vasyliev
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  2. A. E. Rodnichenko
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  3. S. N. Shamalo
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  4. A. S. Demidchouk
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  5. I. F. Labunets
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  6. Yu. B. Chaikovskii
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  7. G. M. Butenko
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Correspondence to Yu. B. Chaikovskii.

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Vasyliev, R.G., Rodnichenko, A.E., Shamalo, S.N. et al. Effects of Neural Crest-Derived Multipotent Stem Cells on Regeneration of an Injured Peripheral Nerve in Mice. Neurophysiology 47, 80–83 (2015). https://doi.org/10.1007/s11062-015-9501-6

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  • DOI: https://doi.org/10.1007/s11062-015-9501-6

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