Neurotropic effects of new coordination compounds, germacit and stanmacit, were tested on models of acute generalized convulsive activity induced in rats by injections of pentylenetetrazol (PTZ, 40 mg/kg), picrotoxin (PT, 2.0 mg/kg), or kainic acid (KA, 15 mg/kg). The tested biologically active substances were injected in doses corresponding to 1/10, 1/20, 1/40, 1/80, or 1/135 of the calculated LD50. Germacit provided obvious anticonvulsive effects in the case of seizure activity induced by PTZ (in a dose of 1/80 LD50), PT, and KA (in doses of 1/40 LD50); the intensity of convulsive manifestations decreased significantly compared with analogous indices in control groups (P < 0.05). Stanmacit did not influence the expression of acute PT-induced convulsions (P > 0.05) but intensified PTZ- and KA-induced seizures (at 1/20 and 1/40 LD50, respectively; P < 0.05). The obtained data are indicative of the ability of new complex coordination compounds of germanium and tin with magnesium and citric acid to significantly control the excitability of cerebral structures involved in the generation of epileptiform activity.
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References
I. I. Seifullina, O. D. Nemyatykh, V. D. Kuk’yanchouk, et al., “Pharmacological effects of germanium-organic compounds,” Odessa Med. Zh., No. 6, 110-114 (2003).
O. I. Varbanets’ “Examination of interaction of new xylarate germanium complex (IV) with potassium ions and anticonvulsive preparations under conditions of a model of 6-Hz-induced convulsions in mice,” Klin. Éksp. Patol., 9, Part 1, No. 3, 19-23 (2012).
O. H. Shandra, D. B. Voloshenko, and V. V. Godovan, “Effect of new compound of germanium with nicotinamide on different forms of convulsive syndrome,” Odess Med. Zh., No. 2, 22-25 (2005).
P. A. Abdelmalik, N. Politzer, and P. L. Carlen, “Magnesium as an effective adjunct therapy for drug resistant seizures,” Can. J. Neurol. Sci., 39, No. 3, 323-327 (2012).
A. Sen and A. Gulati, “Use of magnesium in traumatic brain injury,” Neurotherapeutics, 7, No. 1, 91-99 (2010).
A. Verma, S. Sharma, K. B. Bansal, et al., “Some new coordination compounds of tin (II) and lead (II) with Schiff bases rearranged from benzothiazolines,” RASAYAN J. Chem., 3, No. 3, 545-549 (2010).
A. A. Shandra, L. S. Godlevsky, and A. I. Brusentsov, Kindling and Epileptic Activity [in Russian], AstroPrint, Odessa (1999).
D. M. Woodbury, “Convulsant drugs: Mechanisms of action,” in: Antiepileptic Drugs: Mechanism of Action, Raven Press, New York (1980), pp. 249-303.
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Matyushkina, M.V. Effects of New Coordination Compounds of Ge, Sn, and Mg on Acute Generalized Convulsive Activity in Rats. Neurophysiology 46, 370–372 (2014). https://doi.org/10.1007/s11062-014-9461-2
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DOI: https://doi.org/10.1007/s11062-014-9461-2