Skip to main content

Advertisement

Log in

Redistribution of Cell Adhesion Proteins in the Brain and the Peculiarities of Behavioral Phenomena in Rats with Chronic Pancreatitis

  • Published:
Neurophysiology Aims and scope

We demonstrated that, under conditions of the development of experimental pancreatitis accompanied by a decrease in locomotor and orientational-research activity of animals and also by the development of the stress state, concentrations of the soluble and membrane isoforms of neuronal cell adhesion molecule (NCAM) change in the cerebellum and thalamus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Yu. M. Stepanov and N. G. Zaichenko, “Chronic pancreatitis: biliary mechanism, factors, and time course,” Zaporozh. Med. Zh., 70, No. 1, 46-50 (2012).

    Google Scholar 

  2. R. K. Tandon and P. K. Garg, “Oxidative stress in chronic pancreatitis: pathophysiological relevance and management,” Antioxidants Redox Signal., 15, No. 10, 2757-2766 (2011).

    Article  CAS  Google Scholar 

  3. C. Çöl, K. Dinler, O. Hasdemir, et al., “Oxidative stress and lipid peroxidation products: effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis,” Hepatobiliary Pancreat. Dis. Int., 9, No. 1, 78-82 (2010).

    PubMed  Google Scholar 

  4. A. Catalá, “Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions,” Chem. Phys. Lipids, 157, 1-11 (2009).

    Article  PubMed  Google Scholar 

  5. D. Zhen, L. Jun, L. Rong, and H. Xiao Hua, “Experimental pancreatitis results in increased bloodbrain barrier permeability in rats: A potential role of MCP-1,” J. Digest. Dis., 13, 179-185 (2012).

    Article  Google Scholar 

  6. B. J. Page, D. F. Toit, C. Muller, et al., “An immunocytochemical profile of the endocrine pancreas using an occlusive duct ligation model,” J. Pancreas, 4, No. 1, 191-203 (2000).

    Google Scholar 

  7. T. T Ngo, H. M. Lenhoff, and A. Yaklich, Enzyme-Mediated Immunoassay [Russian translation], Mir, Moscow (1988).

    Google Scholar 

  8. M. Bradford, “Rapid and sensitive methods for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding,” Anal. Biochem., 72, 248-254 (1985).

    Article  Google Scholar 

  9. J. Bureš, O. Burešova, and J. Hewstone, Technique and Basic Experiments for Studying the Brain and Behavior [Russian translation], Vyssh. Shkola, Moscow (1991).

    Google Scholar 

  10. A. Petrie and C. Sabin, Medical Statistics at a Glance [Russian translation], Geotar-Med, Moscow (2003).

    Google Scholar 

  11. L. H. Brennaman and P. F. Maness, “NCAM in neuropsychiatric and neurodegenerative disorders,” Adv. Exp. Med. Biol., 663, 299-317 (2010).

    Article  CAS  PubMed  Google Scholar 

  12. M. Hagiyama, N. Ichiyanagi, K. B. Kimura, et al., “Expression of a soluble isoform of cell adhesion molecule 1 in the brain and its involvement in directional neurite outgrowth,” Am. J. Pathol., 174, No. 6, 2278-2289 (2009).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. S. Zecchini, L. Bombardelli, A. Decio, et al., “The adhesion molecule NCAM promotes ovarian cancer progression via FGFR signaling,” EMBO Mol. Med., 3, 480-494 (2011).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  14. R. Kleene, M. Mzoughi, G. Joshi, et al., “NCAMinduced neurite outgrowth depends on binding of calmodulin to NCAM and on nuclear import of NCAM and fak fragments,” J. Neurosci., 32, No. 30, 10784-10798 (2010).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to V. A. Makarchouk.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Makarchouk, V.A., Ushakova, G.O. Redistribution of Cell Adhesion Proteins in the Brain and the Peculiarities of Behavioral Phenomena in Rats with Chronic Pancreatitis. Neurophysiology 46, 177–179 (2014). https://doi.org/10.1007/s11062-014-9425-6

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11062-014-9425-6

Keywords

Navigation