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The clinical features and surgical outcomes of intracranial tanycytic ependymomas: a single-institutional experience

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Abstract

Tanycytic ependymoma is a rare subtybe of ependymoma with a predilection for the spinal cord and intracranial tanycytic ependymoma is thus extremely rare. Most studies on intracranial tanycytic ependymomas included only one or two cases. Here we report nine patients with pathologically confirmed intracranial tanycytic ependymomas. The clinical characteristics, including radiological and histological examination, operative records, and prognoses were reviewed. The case series included six male and three female patients with an average age of 19.3 years. Tumors were located in the lateral ventricle (3/9), the fourth ventricle (2/9), and the supratentorial extraventricle (4/9). Gross total resection (GTR) of the tumor was achieves in seven cases, and subtotal resection (STR) was achieved in the other two cases. One patient died 21 months after discharge. The left eight patients showed improved symptoms after surgery, and no tumor recurrence was found in these cases during the follow-up. It seems that intracranial tanycytic ependymoma has the best long-term prognosis compared to the other two subtypes of ependymoma. According to our experience, we recommend surgery including GTR and STR followed by radiotherapy for patients with intracranial tanycytic ependymomas.

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Acknowledgements

The authors thank all the patients who trusted them and all the physicians and staff who helped them in this study.

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Authors and Affiliations

  1. Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, 6 Tiantan Xili, Dongcheng District, Beijing, 100050, People’s Republic of China

    Xiaogang Tao, Jinqian Dong, Zonggang Hou, Shuyu Hao, Zhen Wu, Junting Zhang & Baiyun Liu

  2. Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA

    Qi Zhang

  3. Department of Neurotrauma, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100050, China

    Baiyun Liu

  4. Nerve Injury and Repair Center of Beijing Institute for Brain Disorders, Beijing, 100050, China

    Baiyun Liu

  5. China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China

    Baiyun Liu

  6. Beijing Key Laboratory of Central Nervous System Injury, Beijing, 100050, China

    Baiyun Liu

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  1. Xiaogang Tao
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  2. Jinqian Dong
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  3. Zonggang Hou
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  4. Shuyu Hao
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  5. Qi Zhang
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  6. Zhen Wu
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  7. Junting Zhang
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  8. Baiyun Liu
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Correspondence to Baiyun Liu.

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Conflict of interest

The authors report no conflict of interest concerning the materials or methods used in this study or the findings described in this paper. No benefits in any form have been or will be received from any commercial party related directly or indirectly to the subject of this manuscript.

Ethical approval

This retrospective study was approved by Institutional Review Board of Beijing Tian Tan Hospital, Capital Medical University.

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Tao, X., Dong, J., Hou, Z. et al. The clinical features and surgical outcomes of intracranial tanycytic ependymomas: a single-institutional experience. J Neurooncol 134, 339–347 (2017). https://doi.org/10.1007/s11060-017-2531-8

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  • DOI: https://doi.org/10.1007/s11060-017-2531-8

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