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Influence of glioblastoma contact with the lateral ventricle on survival: a meta-analysis

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Abstract

The ventricular-subventricular zone (V-SVZ), which lies in the walls of the lateral ventricles (LV), is the largest neurogenic niche within the adult brain. Whether radiographic contact with the LV influences survival in glioblastoma (GBM) patients remains unclear. We assimilated and analyzed published data comparing survival in GBM patients with (LV+GBM) and without (LV-GBM) radiographic LV contact. PubMed, EMBASE, and Cochrane electronic databases were searched. Fifteen studies with survival data on LV+GBM and LV-GBM patients were identified. Their Kaplan–Meier survival curves were digitized and pooled for generation of median overall (OS) and progression free (PFS) survivals and log-rank hazard ratios (HRs). The log-rank and reported multivariate HRs after accounting for the common predictors of GBM survival were analyzed separately by meta-analyses. The calculated median survivals (months) from pooled data were 12.95 and 16.58 (OS), and 4.54 and 6.25 (PFS) for LV+GBMs and LV-GBMs, respectively, with an overall log-rank HRs of 1.335 [1.204–1.513] (OS) and 1.387 [1.225–1.602] (PFS). Meta-analysis of log-rank HRs resulted in summary HRs of 1.58 [1.35–1.85] (OS, 10 studies) and 1.41 [1.22–1.64] (PFS, 5 studies). Meta-analysis of multivariate HRs resulted in summary HRs of 1.35 [1.14–1.58] (OS, 6 studies) and 1.64 [0.88–3.05] (PFS, 3 studies). Patients with GBM contacting the LV have lower survival. This effect may be independent of the common predictors of GBM survival, suggesting a clinical influence of V-SVZ contact on GBM biology.

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Acknowledgements

We thank Dr. Tseng for providing unpublished Kaplan–Meier survival curves of LV+GBM and LV-GBM patient data analyzed in the study Liang et al. [22].

Funding

This work was by supported a grant from the Institute for Clinical and Translational Research, Vanderbilt University, part of the National Center for Advancing Translational Sciences, CTSA award No. UL1TR000445 (A.M.M.) and Discovery Grants from the Vanderbilt-Ingram Cancer Center (R.A.I.).

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  1. Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, 37212, USA

    Akshitkumar M. Mistry, Lola B. Chambless, Kyle D. Weaver, Reid C. Thompson & Rebecca A. Ihrie

  2. Department of Cancer Biology, Vanderbilt University, Nashville, TN, 37232-6840, USA

    Rebecca A. Ihrie

  3. Medical Scientist Training Program, Vanderbilt University Medical Center, Nashville, TN, 37212, USA

    Andrew T. Hale

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Mistry, A.M., Hale, A.T., Chambless, L.B. et al. Influence of glioblastoma contact with the lateral ventricle on survival: a meta-analysis. J Neurooncol 131, 125–133 (2017). https://doi.org/10.1007/s11060-016-2278-7

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