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Clinical improvement and survival in breast cancer leptomeningeal metastasis correlate with the cytologic response to intrathecal chemotherapy

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Abstract

Leptomeningeal meningitis occurs in approximately 5% of metastatic breast cancers, and there is no standard treatment for this complication. We retrospectively analyzed the clinical data and cerebrospinal fluid of 24 patients treated with high-dose intrathecal methotrexate for breast cancer leptomeningeal meningitis (BLM). Cytologic response (CSF cytology without neoplastic cells after treatment) was observed in 11 patients (46%) and related to survival (P = 0.005). In addition, clinical symptoms improved in all 11 patients who had a cytologic response and in 7 patients (54%) without cytologic response (P = 0.02). The predictive value of cytologic response needs further confirmation. Cytologic response could be helpful in the management of intrathecal chemotherapy in patients with BLM.

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Authors and Affiliations

  1. Département d’Oncologie Médicale, Centre Henri-Becquerel, Rue d’Amiens, 76038, Rouen Cedex, France

    Florian Clatot, Géraldine Philippin-Lauridant, Matthieu-John Ouvrier, Tony Nakry, Cécile Guillemet, Corinne Veyret & Emmanuel Blot

  2. Service d’Anatomie et Cytologie Pathologiques, Centre Henri-Becquerel, Rue d’Amiens, 76038, Rouen Cedex, France

    Sophie Laberge-Le-Couteulx

Authors
  1. Florian Clatot
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  2. Géraldine Philippin-Lauridant
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  3. Matthieu-John Ouvrier
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  4. Tony Nakry
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  5. Sophie Laberge-Le-Couteulx
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  6. Cécile Guillemet
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  7. Corinne Veyret
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  8. Emmanuel Blot
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Correspondence to Emmanuel Blot.

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Clatot, F., Philippin-Lauridant, G., Ouvrier, MJ. et al. Clinical improvement and survival in breast cancer leptomeningeal metastasis correlate with the cytologic response to intrathecal chemotherapy. J Neurooncol 95, 421–426 (2009). https://doi.org/10.1007/s11060-009-9940-2

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  • DOI: https://doi.org/10.1007/s11060-009-9940-2

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