Abstract
Secondary brain tumors rarely arise after cranial irradiation; among them, meningiomas and glioblastomas are the most common and secondary oligodendroglial tumors the most rare. We present a 48-year-old man who developed an oligodendroglial tumor 38 years after receiving 50 Gy of cranial irradiation to a pineal tumor. He underwent gross total removal of a calcified, ring-enhanced mass in the right temporal lobe. The tumor was histologically diagnosed as anaplastic oligodendroglioma. Our review of previously reported secondary oligodendroglial tumors that developed after cranial irradiation revealed that these rare tumors arose after low-dose cranial irradiation or at the margin of a field irradiated with a high dose. We suggest that secondary oligodendroglial tumors arising after cranial irradiation are more aggressive than primary oligodendrogliomas.
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References
Minniti G, Traish D, Ashley S, Gonsalves A, Brada M (2005) Risk of second brain tumor after conservative surgery and radiotherapy for pituitary adenoma: update after an additional 10 years. J Clin Endocrinol Metab 90:800–804
Al-Mefty O, Kersh J, Routh A, Smith R (1990) The long-term side effects of radiation therapy for benign brain tumors in adults. J Neurosurg 73:502–512
Ron E, Modan B, Boice JJ et al (1988) Tumors of the brain and nervous system after radiotherapy in childhood. N Engl J Med 319:1033–1039
Tsang R, Laperriere N, Simpson W, Brierley J, Panzarella T, Smyth H (1993) Glioma arising after radiation therapy for pituitary adenoma. A report of four patients and estimation of risk. Cancer 72:2227–2233
Zuccarello M, Sawaya R, deCourten-Meyers G (1986) Glioblastoma occurring after radiation therapy for meningioma: case report and review of literature. Neurosurgery 19:114–119
Fontana M, Stanton C, Pompili A et al (1987) Late multifocal gliomas in adolescents previously treated for acute lymphoblastic leukemia. Cancer 60:1510–1518
Huang C, Chiou W, Ho D (1987) Oligodendroglioma occurring after radiation therapy for pituitary adenoma. J Neurol Neurosurg Psychiat 50:1619–1624
Palma L, Vagnozzi R, Annino L, Ciapetta P, Maleci A, Cantore G (1988) Post-radiation glioma in a child. Case report and review of the literature. Childs Nerv Syst 4:296–301
Corn B, Curtis M, Lynch D, Gomori J (1994) Malignant oligodendroglioma arising after radiation therapy for lymphoma. Med Pediatr Oncol 22:45–52
Panigrahi S, Das M, Stagler D et al (2003) Development of secondary anaplastic oligoastrocytoma after matched unrelated bone marrow transplantation in a child with acute myeloid leukemia. Acta Haematol 109:196–198
Tanriover N, Ulu M, Sar M, Uzan M (2007) Anaplastic oligoastrocytoma: previous treatment as a possible cause in a child with acute lymphoblastic leukemia. Childs Nerv Syst 23:469–473
Kisileva E, Goldobenko G, Kanaev S (1996) Radiation therapy of malignant tumors. Medicina, Moscow, (in Russian)
Stelzer K (2000) Acute and long-term complications of therapeutic radiation for skull base tumors. Neurosurg Clin North Amer 11:597–604
Ellen EM (1999) Radiation-induced tumors. In: Berger MS, Wilson CB (eds) Gliomas, 1st edn. Saunders, Philadelphia, pp 724–735
Cahan W, Woodward H, Higinbotham N (1948) Sarcoma arising in irradiated bone: report of eleven cases. Cancer 1:3–29
Rubinstein A, Shalit M, Cohen M (1984) Radiation-induced cerebral meningioma: a recognizable entity. J Neurosurg 61:966–971
Verheyde J, Benotmane MA (2007) Unraveling the fundamental molecular mechanisms of morphological and cognitive defects in the irradiated brain. Brain Res Rev 53:312–320
Louis D, Ohgaki H, Wiestler O, Kleihues P (2006) WHO classification of tumours of the central nervous system. IARC Press, Lyon
Nagayama K, Kurita H, Nakamura M et al (2005) Radiation-induced apoptosis of oligodendrocytes in the adult rat optic chiasm. Neurol Res 27:346–350
Cairncross J, Ueki K, Zlatescu M et al (1998) Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J Natl Cancer Inst 90:1473–1479
Ino Y, Betensky R, Zlatescu C et al (2001) Molecular subtypes of anaplastic oligodendroglioma: implications for patient management at diagnosis. J Clin Cancer Res 7:839–845
Smith J, Perry A, Borell T et al (2000) Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas. J Clin Oncol 18:636–645
Spiro T, Liu L, Majka S, Haaga J, Willson J, Gerson S (2001) Temozolomide: the effect of once- and twice-a-day dosing on tumor tissue levels of the DNA repair protein O6-alkylguanine-DNA-alkyltransferase. Clin Cancer Res 7:2309–2317
Tolcher A, Gerson S, Denis L (2003) Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules. Br J Cancer 88:1004–1011
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Doskaliyev, A., Yamasaki, F., Kenjo, M. et al. Secondary anaplastic oligodendroglioma after cranial irradiation: a case report. J Neurooncol 88, 299–303 (2008). https://doi.org/10.1007/s11060-008-9564-y
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DOI: https://doi.org/10.1007/s11060-008-9564-y