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Spontaneously relapsing and remitting primary CNS lymphoma in an immunocompetent 45-year-old man

  • Clinical–Patient Studies
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Abstract

A 45-year-old immunocompetent man with primary central nervous system lymphoma (PCNSL) presented with multiple spontaneous relapses and remissions in the absence of steroid treatment. Because of the fluctuations with improvement in both the clinical course and MRI findings, alternative disorders were considered that led to delay of diagnosis and treatment prior to brain biopsy. This case and a handful of others with single remissions emphasize that PCNSL cannot be reliably ruled out by improving or␣disappearing symptoms, signs or traditional MR imaging abnormalities.

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References

  1. Al-Yamany M, Lozano A, Nag S, Laperriere N, Bernstein M (1999) Spontaneous remission of primary central nervous system lymphoma: report of 3 cases and discussion of pathophysiology. J Neurooncol 42:151–159

    Article  PubMed  CAS  Google Scholar 

  2. Kon T, Kakita A, Koide A, Mori H, Tanaka R, Takahashi H (2003) A primary CNS lymphoma in spontaneous remission for 3.5 years after initial detection of the lesions by MRI. Brain Tumor Pathol 20:27–31

    Article  PubMed  Google Scholar 

  3. Weingarten KL, Zimmerman RD, Leeds NE (1983) Spontaneous regression of intracerebral lymphoma. Radiology 149:721–724

    PubMed  CAS  Google Scholar 

  4. Abrey LE, Yahalom J, DeAngelis LM (2000) Treatment for primary CNS lymphoma: the next step. J Clin Oncol 18:3144–3150

    PubMed  CAS  Google Scholar 

  5. Bataille B, Delwail V, Menet E, Vandermarcq P, Ingrand P, Wager M, Guy G, Lapierre F (2000) Primary intracerebral malignant lymphoma: report of 248 cases. J Neurosurg 92:261–266

    Article  PubMed  CAS  Google Scholar 

  6. Buell WF, Hart RG (1988) Spontaneous temporary remission in primary CNS lymphoma. Can J Neurol Sci 15:88

    PubMed  CAS  Google Scholar 

  7. Palmedo H, Urbach H, Bender H, Schlegel U, Schmidt-Wolf IG, Matthies A, Linnebank M, Joe A, Bucerius J, Biersack HJ, Pels H (2006) FDG-PET in immunocompetent patients with primary central nervous system lymphoma: correlation with MRI and clinical follow-up. Eur J Nucl Med Mol Imaging 33:164–168

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, University of Washington School of Medicine, Seattle, WA, 98195, USA

    Sonia Partap & Alexander M. Spence

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  1. Sonia Partap
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  2. Alexander M. Spence
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Correspondence to Alexander M. Spence.

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Partap, S., Spence, A.M. Spontaneously relapsing and remitting primary CNS lymphoma in an immunocompetent 45-year-old man. J Neurooncol 80, 305–307 (2006). https://doi.org/10.1007/s11060-006-9192-3

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  • DOI: https://doi.org/10.1007/s11060-006-9192-3

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