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Intracranial Nasal Natural Killer/T-cell Lymphoma: Immunopathologically-Confirmed Case and Review of Literature

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Summary

Advances in immunophenotypic profiling now permit characterization of natural killer/T-cell (NK/T-cell) lymphoma as distinct from other extranodal T- and B-cell Non-Hodgkin’s lymphomas. NK/T-cell lymphoma presents most commonly in the nasal cavity. Disease progression to the central nervous system (CNS) is a rare phenomenon. We present here, to our knowledge, the first immunophenotypically-confirmed case of direct extension of nasal NK/T-cell lymphoma to the brain. In addition, we review the literature with respect to NK/T-cell lymphoma metastasis to the CNS. The overall prevalence of NK/T-cell lymphoma CNS metastasis is less than 3%. Although rare, CNS invasion portends a poor prognosis, emphasizing the importance of early and accurate immunophenotype profiling and the need for novel, aggressive therapy.

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Authors and Affiliations

  1. Department of Neurological Surgery, New York-Presbyterian Hospital, Weill Cornell Medical College, 525 E. 68th street, Box # 99, New York, NY, USA

    Neal Luther, Jeffrey P. Greenfield & Theodore H. Schwartz

  2. Department of Pathology, Division of Immunopathology, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, NY, USA

    Amy Chadburn

Authors
  1. Neal Luther
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  2. Jeffrey P. Greenfield
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  3. Amy Chadburn
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  4. Theodore H. Schwartz
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Correspondence to Theodore H. Schwartz.

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Luther, N., Greenfield, J.P., Chadburn, A. et al. Intracranial Nasal Natural Killer/T-cell Lymphoma: Immunopathologically-Confirmed Case and Review of Literature. J Neurooncol 75, 185–188 (2005). https://doi.org/10.1007/s11060-005-1862-z

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  • DOI: https://doi.org/10.1007/s11060-005-1862-z

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