Abstract
Von Hippel-Lindau Disease, a multisystem familial cancer syndrome, is inherited as an autosomal-dominant trait. Common manifestations of the disease are retinal, cerebellar and medullary hemangioblastomas; renal cysts and carcinomas; pancreatic cysts; pheochromocytoma; and papilllary cystadenoma of the epididym. We report the case of a 40-year-old man with type I von Hippel-Lindau disease treated with external radiotherapy for recurrent cerebellar hemangioblastoma.
Similar content being viewed by others
References
ER Maher L Iselius JR Yates (1991) ArticleTitleVon Hippel-Lindau disease: a genetic study J Med Genet 28 443–447 Occurrence Handle1:STN:280:By6A2svkslM%3D Occurrence Handle1895313
F Latif K Tory J Gnarra (1993) ArticleTitleIdentification of the von Hippel-Lindau disease tumor suppressor gene Science 260 1317–1320 Occurrence Handle1:CAS:528:DyaK3sXks12htbc%3D Occurrence Handle8493574
SM Huson PS Harper MD Hourihan G Cole RD Weeks DA Compston (1986) ArticleTitleCerebellar haemangioblastoma and von Hippel-Lindau disease Brain 109 1297–1310 Occurrence Handle3790978
HPH Neumann OD Wiestler (1991) ArticleTitleClustering of features of von Hippel-Lindau syndrome: evidence for a complex genetic locus Lancet 337 1052–1054 Occurrence Handle10.1016/0140-6736(91)91705-Y Occurrence Handle1:STN:280:By6B3M7ltVA%3D Occurrence Handle1673491
C Stolle G Glenn B Zbar (1998) ArticleTitleImproved detection of germline mutations in the von Hippel-Lindau disease tumor suppressor gene Hum Mutat 12 417–423 Occurrence Handle10.1002/(SICI)1098-1004(1998)12:6<417::AID-HUMU8>3.0.CO;2-K Occurrence Handle1:CAS:528:DyaK1cXnsVyksb4%3D Occurrence Handle9829911
DI Sung CH Chang L Harisiadis (1982) ArticleTitleCerebellar hemangioblastomas Cancer 49 553–555 Occurrence Handle1:STN:280:Bi2C3snlslU%3D Occurrence Handle7199372
V Couch NM Lindor PS Karnes VV Michels (2000) ArticleTitleVon Hippel-Lindau disease Mayo Clin Proc 75 265–272 Occurrence Handle1:CAS:528:DC%2BD3cXit1Wksro%3D Occurrence Handle10725953
S Lodrini G Lasio C Cimino F Pluchino (1991) ArticleTitleHemangioblastomas: clinical characteristics, surgical results and immunohistochemical studies J Neuro Sci 35 179–185 Occurrence Handle1:STN:280:By2B2M7kslM%3D
HP Neumann HR Eggert K Weigel H Friedburg OD Wiestler P Schollmeyer (1989) ArticleTitleHemangioblastomas of the central nervous system. A 10-year study with special reference to von Hippel-Lindau syndrome J Neurosurg 70 24–30, 1989 Occurrence Handle1:STN:280:BiaD1c%2FotlA%3D Occurrence Handle2909683
SR Smalley PJ Schomberg JD Earle ER Laws SuffixJr BW Scheithauer JR O’Fallon (1990) ArticleTitleRadiotherapeutic considerations in the treatment of hemangioblastomas of the central nervous system Int J Radiat Oncol Biol Phys 18 1165–1171
RG Richardson TW Griffin RG Parker (1980) ArticleTitleIntramedullary hemangioblastoma of the spinal cord: definitive management with irradiation Cancer 45 49–52 Occurrence Handle1:STN:280:Bi%2BD1cbntlc%3D Occurrence Handle7188680
KA Page K Wayson GK Steinberg (1993) ArticleTitleStereotaxic radiosurgical ablation: an alternative treatment for recurrent and multifocal hemangioblastomas Surg Neurol 40 424–428 Occurrence Handle10.1016/0090-3019(93)90225-P Occurrence Handle1:STN:280:ByuD38vlt10%3D Occurrence Handle8211662
M Niemelä YJ Lim M Söderman J Jääskeläinen C Lindquist (1996) ArticleTitleGamma knife radiosurgery in 11 hemangioblastomas J Neurosurg 85 591–596 Occurrence Handle1:STN:280:BymH3cbhsl0%3D Occurrence Handle8814161
SJ Patrice PK Sneed JC Flickinger DC Shrieve BE Pollock E Alexander SuffixIII DA Larson DS Kondziolka PH Gutin WM Wara MW McDermott LD Lunsford JS Loeffler (1996) ArticleTitleRadiosurgery for hemangioblastoma: results of a multi-institutional experience Int J Radiat Oncol Biol Phys 35 493–499 Occurrence Handle1:STN:280:BymB2s3hvVw%3D Occurrence Handle8655372
SD Chang JA Meisel SL Hancock DP Martin M McManus JR Adler SuffixJr (1998) ArticleTitleTreatment of hemangioblastomas in von Hippel-Lindau disease with linear accelerator-based radiosurgery Neurosurgery 43 28–34 Occurrence Handle1:STN:280:DyaK1czhvFaltQ%3D%3D Occurrence Handle9657185
ER Maher JRW Yates R Harries (1990) ArticleTitleClinical features and natural history of von Hippel-Lindau disease Q J Med 77 1151–1163 Occurrence Handle1:STN:280:By6C3M%2Foslc%3D Occurrence Handle2274658
PL Choyke GM Glenn MM Walther NJ Patronas WM Linehan B Zbar (1995) ArticleTitleVon Hippel-Lindau disease: genetic, clinical and imaging features Radiology 194 629–642 Occurrence Handle1:STN:280:ByqC28jhtVY%3D Occurrence Handle7862955
S Richard C Campello L Taillandier F Parker F Resche (1998) ArticleTitleHaemangioblastoma of the central nervous system in von Hippel-Lindau disease. French VHL study group J Int Med 243 547–553 Occurrence Handle10.1046/j.1365-2796.1998.00337.x Occurrence Handle1:CAS:528:DyaK1cXks1Wkurk%3D
N Karsdorp A Elderson D Wittebol-Post RJ Hene J Vos MA Feldberg AP Gils Particlevan JM Jansen-Schillhornvan Veen TM Vroom JW Hoppener (1994) ArticleTitleVon Hippel-Lindau disease: new strategies in early detection and treatment Am J Med 97 158–168 Occurrence Handle10.1016/0002-9343(94)90026-4 Occurrence Handle1:STN:280:ByuA3sjnvVc%3D Occurrence Handle8059782
JE Wanebo RR Lonser GM Glenn EH Oldfield (2003) ArticleTitleThe natural history of hemangioblastomas of the central nervous system in patients with von Hippel-Lindau disease J Neurosurg 98 82–94 Occurrence Handle12546356
A Slater NR Moore SM Huson (2003) ArticleTitleThe natural history of cerebellar hemangioblastomas in von Hippel-Lindau disease Am J Neuroradiol 24 1570–1574 Occurrence Handle13679272
HP Neumann HR Eggert R Scheremet M Schumacher M Mohadjer AK Wakhloo B Volk U Hettmannsperger P Riegler P Schollmeyer (1992) ArticleTitleCentral nervous system lesions in von Hippel-Lindau syndrome J Neurol Neurosurg Psychiat 55 898–901 Occurrence Handle1:STN:280:ByyD2MjlvV0%3D Occurrence Handle1431953
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ertas, G., Altundag, M.B., Ucer, A.R. et al. Treatment of recurrent cerebellar hemangioblastoma with external radiotherapy in a patient with von Hippel-Lindau disease: a case report and review of the literature. J Neurooncol 73, 273–275 (2005). https://doi.org/10.1007/s11060-004-5179-0
Issue Date:
DOI: https://doi.org/10.1007/s11060-004-5179-0