The aim of the present work was to study the distribution of cell contact protein β-catenin in the choroid plexus and ependyma of the lateral ventricles of the brain. Experiments were performed using frontal sections of brains from Wistar rats (n = 10) using polyclonal antibodies to β-catenin. Preparations were analyzed under the microscope in transmitted light and by confocal laser microscopy. The distribution of β-catenin in different projections was studied by three-dimensional reconstruction. The results identified differences in the distributions of this protein in the ependyma and choroid plexus. In contrast to the ependyma, β-catenin is distributed in choroid plexus cells in the same way as in monolayer epithelial tissues (at the basal and lateral margins of the cells). This may be evidence that the ependyma and epithelium of the choroid plexus are of different tissue types, despite their common origin.
Similar content being viewed by others
References
O. V. Kirik, D. A. Sufieva, A. V. Nazarenkova, and D. E. Korzhevskii, “Structural organization of the processes of the ependymocytes forming the pavement of the lateral ventricles of the brain,” Morfologiya, 147, No. 2, 17–21 (2015).
D. E. Korzhevskii, The Epithelium of the Choroid Plexus, SpetsLit, St. Petersburg (2001), Vol. 1, pp. 177–179.
D. E. Korzhevskii, E. G. Sukhorukova, E. G. Gilerovich, et al., “Advantages and drawbacks of zinc-ethanol-formaldehyde as a fixative for immunocytochemical studies and confocal laser microscopy,” Morfologiya, 143, No. 2, 81–85 (2013).
V. V. Banin and V. L. Bykova (eds.), International Terms in Human Cytology and Histology with an Official List of Russian Equivalents, GEOTAR-Media, Moscow (2009).
C. Giachino, O. Basak, S. Lugert, et al., “Molecular diversity subdivides the adult forebrain neural stem cell population,” Stem Cells, 32, No. 1, 70–84 (2014).
R. B. Meeker, D. C. Bragg, W. Poulton, and L. Hudson, “Transmigration of macrophages across the choroid plexus epithelium in response to the feline immunodeficiency virus,” Cell Tiss. Res., 347, No. 2, 443–455 (2012).
J. Nürnberger, T. Feldkamp, R. Kavapurackal, et al., “N-cadherin is depleted from proximal tubules in experimental and human acute kidney injury,” Histochem. Cell Biol., 133, No. 6, 641–649 (2010).
S. Tyler, “Epithelium. The primary building block for metazoan complexity,” Integr. Comp. Biol., 43, 55–63 (2003).
T. Valenta, G. Hausmann, and K. Basler, “The many faces and functions of β-catenin,” EMBO J., 31, 2714–2736 (2012).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Morfologiya, Vol. 149, No. 1, pp. 33–37, Januray–February, 2016.
Rights and permissions
About this article
Cite this article
Kirik, O.V., Sufieva, D.A., Nazarenkova, A.V. et al. Cell Contact Protein β-Catenin in Ependymal and Epithelial Cells in the Choroid Plexus of the Lateral Ventricles of the Brain. Neurosci Behav Physi 47, 117–121 (2017). https://doi.org/10.1007/s11055-016-0373-z
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11055-016-0373-z