The influences of hippocampal fields CA1 and CA3 on the spike activity of respiratory neurons in the bulbar respiratory center were studied in normal conditions and hypoxia. In normoxia, stimulation of hippocampal fields CA1 and CA3 had mainly inhibitory influences. During oxygen insufficiency, the activity responses of respiratory neurons in the bulbar respiratory center to stimulation of these structures were phasic. At the beginning of the “elevation” to an “altitude” of 4000–5000 m, the small decrease in pO2 in inspired air induced an increase in neuron spike activity. On this background, the inhibitory influence of stimulation of hippocampal fields CA1 and CA3 was more marked than in normoxia. At an “altitude” of 7500–8000 m, with severe oxygen deficit, the inhibitory influences of hippocampal fields CA1 and CA3 were minor on the background of sharp suppression of baseline neuron activity in the respiratory center. Comparative analysis of the activities of inspiratory (IN) and expiratory (EN) neurons at different stages of hypoxia revealed marked differences in their behavior, in that IN had relatively greater resistance to hypoxia than EN. Among subgroups of IN, early and complete IN were more resistant to oxygen deficit. After the “descent” of the animals to normal atmospheric pressure, there was gradual recovery of the initial values of both spontaneous phasic neuron activity and responses to stimuli.
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N. S. Akopyan (Deceased).
Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 97, No. 2, pp. 169–179, February, 2011.
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Arutyunyan, R.S., Adamyan, N.Y., Karapetyan, M.A. et al. Regulatory Influences of Hippocampal Fields CA1 and CA3 on Bulbar Respiratory Neurons in Conditions of Hypoxia. Neurosci Behav Physi 42, 620–627 (2012). https://doi.org/10.1007/s11055-012-9612-0
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DOI: https://doi.org/10.1007/s11055-012-9612-0