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Aftereffects of microinjections of neurotensin into the substantia nigra of the brain on conditioned motor responses in rats with lesions to serotoninergic neurons

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Abstract

The effects of neurotensin microinjections into the substantia nigra of the brain on the performance of motor reactions in response to positive (food reinforcement) and negative (unreinforced) conditioned signals were studied, along with the characteristic aftereffects of these microinjections in rats with lesions to serotoninergic neurons in the dorsal cervical nucleus. Lesions were produced by local administration of the selective neurotoxin 5,7-dihydroxytryptamine. Microinjections of neurotensin were found to weaken the disinhibitory effects of neurotoxin on extinction of intersignal responses and extinction of conditioned motor reactions in response to presentation of negative stimuli, but to have no marked effect on the performance of reactions evoked by positive conditioned signals. Changes persisted into subsequent experiments without peptide microinjections. Measurements of the level of preference of the animals for one quadrant of the experimental chamber showed that operated rats avoided occupying the test quadrant and preferred to locate themselves in the opposite quadrant. Neurotensin released this effect of the neurotoxin. These results lead to the conclusion that these behavioral effects of neurotensin are associated with its normalizing influences on the motivational-emotional state of the animals with lesions to serotoninergic neurons and may also be due to the formation in the animals of a contextual conditioned emotional state, which aids optimization of the adaptive functions of the brain.

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REFERENCES

  1. E.A. Gromova (1980) Emotional Memory and Its Mechanisms Nauka Moscow

    Google Scholar 

  2. N. P. Shugalev A. S. Ol’shanskii G. Khartmann (2001) ArticleTitleEffects of neurotensin microinjections into the caudate nucleus of the rat brain on the performance and extinction of a conditioned motor reflex Zh. Vyssh. Nerv. Deyat. 51 IssueID4 473–476

    Google Scholar 

  3. N. P. Shugalev A. S. Ol’shanskii G. Khartmann (2000) ArticleTitleBehavioral effects of neurotensin administered into the formations of the nigrostriatal system of the brain Proceedings of the XXX Congress on Questions in Higher Nervous Activity 1 54–55

    Google Scholar 

  4. J. L. Cadet K. Kajoko E. Carlson C. J. Epstein (1993) ArticleTitleAutoradiographic distribution of 3[H] neurotensin receptors in the brain of superoxide dismutase transgenic mice Synapse 14 24–33

    Google Scholar 

  5. R. P. Dilts M. R. Novitzki T. H. Phan et al. (1996) ArticleTitleNeurotensin inhibits the activation of midbrain serotoninergic neurons produced by random inescapable sound Brain Res. 742 IssueID1–2 294–298

    Google Scholar 

  6. A. P. Ford C. A. Marsden (1990) ArticleTitleIn vivo neurochemical and behavioral effects of intracerebrally administered neurotensin and D-Trp 11-neurotensin on mesolimbic and nigrostriatal dopaminergic function in the rat Brain Res. 534 IssueID1–2 243–250

    Google Scholar 

  7. K. Fuxe W. O’Connor T. Antonelli (1992) ArticleTitleEvidence for substrate of neuronal plasticity based on pre- and postsynaptic neurotensindopamine receptor interaction in the neostriatum Proc. Natl. Acad. Sci. USA 89 5591–5594

    Google Scholar 

  8. P. W. Glimcher D. H. Margolin A. A. Giovano B. J. Hoebel (1984) ArticleTitleNeurotensin: A new reward peptide Brain Res. 291 IssueID1 119–124

    Google Scholar 

  9. R. E. Hokfelt B. J. Everitt E. Thedorsson-Norhrim M. Goldstein (1984) ArticleTitleOccurrence of neurotensin-like immunoreactivity in subpopulations of hypothalamic, mesencephalic and medullary catecholamine neurons J. Comp. Neurol. 222 IssueID3 543–559

    Google Scholar 

  10. T. Jolash G. K. Aghajanian (1997) ArticleTitleNeurotensin and the serotoninergic system Progr. Neurobiol. 52 IssueID6 455–458

    Google Scholar 

  11. F. B. Jolicoeur M. A. Gagne R. Rivest A. Drumheller S. St.-Pierre (1993) ArticleTitleA typical neuroleptic-like behavioral effects of neurotensin Brain Res. Bull. 32 487–491

    Google Scholar 

  12. P. W. Kalivas C. B. Nemeroff A. J. Prang (1982) ArticleTitleNeuroanatomical site specific modulation of spontaneous motor activity by neurotensin Eur. J. Pharmacol. 78 IssueID4 471–474

    Google Scholar 

  13. B. Levant C. B. Nemeroff (1992) ArticleTitleFurther studies on the modulation of regional brain neurotensin concentration by antipsychotic drugs: focus on haloperidol and BMY 14802 J. Pharmacol. Exptl. Ther. 262 IssueID2 348–355

    Google Scholar 

  14. P. P. Rompre (1997) ArticleTitleRepeated activation of neurotensin receptors sensitizes to the stimulant effect of amphetamine Eur. J. Pharmacol. 328 IssueID2–3 131–134

    Google Scholar 

  15. W. X. Shi B. S. Bunney (1991) ArticleTitleEffects of neurotensin on midbrain dopamine neurones: are they mediated by formation of neurotensindopamine complex? Synapse 9 157–164

    Google Scholar 

  16. Z. N. Stove C. B. Nemeroff (1991) ArticleTitleThe electrophysiological action of neurotensin in the central nervous system Life Sci. 49 987–1002

    Google Scholar 

  17. T. R. Werkman C. G. Kruse H. Nievelstein et al. (2000) ArticleTitleNeurotensin attenuates the quinpirol-induced inhibition of the firing rate of dopamine neurons in the rat substantia nigra pars compacta and the ventral tegmental area Neurosci. 95 IssueID2 417–423

    Google Scholar 

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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti, Vol. 53, No. 6, pp. 802–807, November–December, 2003.

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Shugalev, N.P., Khartmann, G. & Kertesh, E. Aftereffects of microinjections of neurotensin into the substantia nigra of the brain on conditioned motor responses in rats with lesions to serotoninergic neurons. Neurosci Behav Physiol 35, 147–151 (2005). https://doi.org/10.1007/s11055-005-0056-7

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