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The dynamics of magnetic nanoparticles exposed to non-heating alternating magnetic field in biochemical applications: theoretical study

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Abstract

In the past decade, magneto-nanomechanical approach to biochemical systems stimulation has been studied intensively. This method involves macromolecule structure local deformation via mechanical actuation of functionalized magnetic nanoparticles (f-MNPs) by non-heating low frequency (LF) alternating magnetic field (AMF). Specificity at cellular or molecular level and spatial locality in nanometer scale are its key advantages as compared to magnetic fluid hyperthermia. However, current experimental studies have weak theoretical basis. Several models of magneto-nanomechanical actuation of macromolecules and cells in non-heating uniform LF AMF are presented in the article. Single core-shell spherical, rod-like, and Janus MNPs, as well as dimers consisting of two f-MNPs with macromolecules immobilized on their surfaces are considered. AMF-induced rotational oscillations of MNPs can affect properties and functioning of macromolecules or cellular membranes attached to them via periodic deformations in nanometer scale. This could be widely used in therapy, in particular for targeted drug delivery, controlled drug release, and cancer cell killing. An aggregate composed of MNPs can affect associated macromolecules by force up to several hundreds of piconewton in the case of MNPs of tens of nanometers in diameter and LF AMF below 1 T. AMF parameters and MNP design requirements for effective in vitro and in vivo magneto-nanomechanical treatment are presented.

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Abbreviations

f-MNP:

Functionalized magnetic nanoparticle

LF:

Low frequency

AMF:

Alternating magnetic field

MRI:

Magnetic resonance imaging

RF MH:

Radiofrequency magnetic hyperthermia

MMA:

Magneto-mechanical actuation

MM:

Macromolecule

SAR:

Specific absorption rate

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Authors and Affiliations

  1. Chemistry Department, Lomonosov Moscow State University, 1-11, Leninsky Gory, Moscow, Russia

    Yuri I. Golovin, Natalia L. Klyachko, Alexander G. Majouga & Alexander V. Kabanov

  2. Nanocenter, G.R. Derzhavin Tambov State University, 33, Internatsionalnaya st, Tambov, Russia

    Yuri I. Golovin, Sergey L. Gribanovsky, Dmitry Y. Golovin & Alexander O. Zhigachev

  3. National Research Technological University “MISIS”, 4, Leninsky ave, Moscow, Russia

    Yuri I. Golovin, Natalia L. Klyachko & Alexander G. Majouga

  4. Center for Nanotechnology in Drug Delivery, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA

    Natalia L. Klyachko, Marina Sokolsky & Alexander V. Kabanov

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  1. Yuri I. Golovin
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  2. Sergey L. Gribanovsky
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  3. Dmitry Y. Golovin
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  4. Alexander O. Zhigachev
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Correspondence to Yuri I. Golovin.

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Funding

This work was supported by the Ministry of Education and Science of the Russian Federation (project no. K1-2014-022, development of the model) and Russian Science Foundation (project no. 14-13-00731, carrying out computer calculations).

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The authors declare that they have no conflict of interest.

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Based on the presentation at the 7th International Conference “Nanoparticles, Nanostructured coatings and microcontainers: technology, properties, applications.”

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Golovin, Y.I., Gribanovsky, S.L., Golovin, D.Y. et al. The dynamics of magnetic nanoparticles exposed to non-heating alternating magnetic field in biochemical applications: theoretical study. J Nanopart Res 19, 59 (2017). https://doi.org/10.1007/s11051-017-3753-6

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