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Investigation on properties of P((MAA-co-DMAEMA)-g-EG) polyampholyte nanogels

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Abstract

P((MAA-co-DMAEMA)-g-EG) polyampholyte nanogels (PANGs) were prepared by distillation-dispersion copolymerization of poly(ethylene glycol) methyl ether methacrylate (MPEGMA), N,N-dimethylaminoethyl methacrylate (DMAEMA), and methacrylic acid (MAA) using acetonitrile (AN) as dispersion medium. The results of FTIR spectra indicate that the composition of P((MAA-co-DMAEMA)-g-EG) PANGs is consistent with the designed structure. The results of TEM and laser particle size analyzer (LPSA) show that P((MAA-co-DMAEMA)-g-EG) PANGs present spherical morphology and a bimodal size distribution after and before swelling. P((MAA-co-DMAEMA)-g-EG) PANGs have typically amphoteric characters responding to pH, whose isoelectric point (IEP) increases with decreasing the ratio of MAA/DMAEMA and equilibrium swelling degree (ESD) is greater than that at IEP when the pH value is distant from IEP. P((MAA-co-DMAEMA)-g-EG) PANGs also represent ionic strength sensitivity. Using the water-soluble chitosan (CS, Mn = 5 kDa) as model drug, in vitro release indicates that CS can be effectively incorporated into PANGs and the release rate of CS at pH 1.89 is an order of magnitude greater than that at pH 8.36. P((MAA-co-DMAEMA)-g-EG) PANGs may be useful in biomedicine, especially in oral drug delivery of biomacromolecule.

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Acknowledgments

This work had been supported by National Natural Science Foundation of China (grant number 30772007), Program for New Century Excellent Talents in University of China and Programme of Introducing Talents of Discipline to Universities (No: B06006).

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  1. School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, P.R. China

    Liandong Deng, Yinglei Zhai, Shutao Guo, Fengmin Jin, Zhaopeng Xie, Xiaohua He & Anjie Dong

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  1. Liandong Deng
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  2. Yinglei Zhai
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Correspondence to Anjie Dong.

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Deng, L., Zhai, Y., Guo, S. et al. Investigation on properties of P((MAA-co-DMAEMA)-g-EG) polyampholyte nanogels. J Nanopart Res 11, 365–374 (2009). https://doi.org/10.1007/s11051-008-9391-2

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