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Anterior and Pan-endophthalmitis Caused by Candida albicans and Aspergillus fumigatus: Report of Two Cases

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Abstract

We report two posttraumatic fungal endophthalmitis cases with anterior and entire segment involvement caused, respectively, by Candida albicans and Aspergillus fumigatus. The anterior endophthalmitis induced by C. albicans presented multifocal lesions with hyphael structures in anterior chamber, but without involvement of posterior vitreous. The pan-endophthalmitis caused by A. fumigatus displayed significant hypopyon and vitritis. Treatment strategies are anterior chamber cleaning for anterior endophthalmitis and vitrectomy for pan-endophthalmitis, excepting systemic and topical antifungal drug applications including intravitreal injection for both types of endophthalmitis. There is a much better outcome in the case with anterior segment involvement than that with entire segment involvement. This case report provides evidence that the different types of posttraumatic fungal endophthalmitis related to different fungal infections indeed existed and should be managed with different strategies.

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References

  1. Lemley CA, Han DP. Endophthalmitis: a review of current evaluation and management. Retina. 2007;7:662–80.

    Article  Google Scholar 

  2. Azad R, Ravi K, Talwar D, Rajpal KN. Pars plana vitrectomy with or without silicone oil endotamponade in post-traumatic endophthalmitis. Graefes Arch Clin Exp Ophthalmol. 2003;241:478–83.

    Article  PubMed  Google Scholar 

  3. Berrocal AM, Scott IU, Miller D, Flynn HW Jr. Endophthalmitis caused by Moraxella species. Am J Ophthalmol. 2001;132:788–90.

    Article  PubMed  CAS  Google Scholar 

  4. Bhagat N, Nagori S, Zarbin M. Post-traumatic infectious endophthalmitis. Surv Ophthalmol. 2001;56:214–51.

    Article  Google Scholar 

  5. Brinton GS, Topping TM, Hyndiuk RA, Aaberg TM, Reeser FH, Abrams GW. Posttraumatic endophthalmitis. Arch Ophthalmol. 1984;102:547–50.

    Article  PubMed  CAS  Google Scholar 

  6. Aggarwal P, Garg P, Sidhu HK, Mehta S. Post-traumatic endophthalmitis with retained intraocular foreign body—a case report with review of literature. Nepal J Ophthalmol. 2012;4:187–90.

    PubMed  CAS  Google Scholar 

  7. Danis RP. Endophthalmitis. Opthalmol Clin N Am. 2002;15:243–8.

    Article  Google Scholar 

  8. Kresloff MS, Castellarin AA, Zarbin MA. Endophthalmitis. Surv Ophthalmol. 1998;43:193–224.

    Article  PubMed  CAS  Google Scholar 

  9. Essex RW, Yi Q, Charles PG, Allen PJ. Post-traumatic endophthalmitis. Ophthalmology. 2004;111:2015–22.

    Article  PubMed  Google Scholar 

  10. Wykoff CC, Flynn HW Jr, Miller D, Scott IU, Alfonso EC. Exogenous fungal endophthalmitis: microbiology and clinical outcomes. Ophthalmology. 2008;115:1501–7.

    Article  PubMed  Google Scholar 

  11. Chhablani J. Fungal endophthalmitis. Expert Rev Anti Infect Ther. 2011;9:111–201.

    Article  Google Scholar 

  12. Gupta A, Srinivasan R, Kaliaperumal S, Saha I. Post-traumatic fungal endophthalmitis—a prospective study. Eye (Lond). 2008;22:13–7.

    Article  CAS  Google Scholar 

  13. Chavan R, Mustafa MZ, Narendran N, Tarin S, Yang Y. A case of Candida albicans endophthalmitis with no predisposing risk factors and a distant source of infection. Case Rep Ophthalmol. 2012;3:277–82.

    Article  PubMed  Google Scholar 

  14. Essman TF, Flynn HW Jr, Smiddy WE, Brod RD, Murray TG, Davis JL, Rubsamen PE. Treatment outcomes in a 10-year study of endogenous fungal endophthalmitis. Ophthalmic Surg Lasers. 1997;28:185–94.

    PubMed  CAS  Google Scholar 

  15. Berman J, Sudbery PE. Candida Albicans: a molecular revolution built on lessons from budding yeast. Nat Rev Genet. 2002;3:918–30.

    Article  PubMed  CAS  Google Scholar 

  16. Riddell Iv J, McNeil SA, Johnson TM, Bradley SF, Kazanjian PH, Kauffman CA. Endogenous Aspergillus endophthalmitis: report of 3 cases and review of the literature. Medicine (Baltimore). 2002;81:311–20.

    Article  Google Scholar 

  17. Chowdhury T, Jalali S, Reddy KS, Sharma S. Candida Albicans endophthalmitis after phacoemulsification and intraocular lens implantation. JK Sci. 2003;5:40–2.

    Google Scholar 

  18. Rao NA, Hidayat AA. Endogenous mycotic endophthalmitis: variations in clinical and histopathologic changes in candidiasis compared with aspergillosis. Am J Ophthalmol. 2001;132:244–51.

    Article  PubMed  CAS  Google Scholar 

  19. Ben-Ami R, Lewis RE, Kontoyiannis DP. Enemy of the (immunosuppressed) state: an update on the pathogenesis of Aspergillus fumigatus infection. Br J Haematol. 2010;150:406–17.

    PubMed  CAS  Google Scholar 

  20. Latge JP. Aspergillus fumigatus and aspergillosis. Clin Microbiol Rev. 1999;12:310–50.

    PubMed  CAS  Google Scholar 

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Correspondence to Tianlin Xiao.

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Wang, A., Cao, J., Hu, S. et al. Anterior and Pan-endophthalmitis Caused by Candida albicans and Aspergillus fumigatus: Report of Two Cases. Mycopathologia 176, 451–456 (2013). https://doi.org/10.1007/s11046-013-9694-4

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  • DOI: https://doi.org/10.1007/s11046-013-9694-4

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